The role of microglia in the healthy brain

MÈ Tremblay, B Stevens, A Sierra, H Wake… - Journal of …, 2011 - Soc Neuroscience
Microglia were recently shown to play unexpected roles in normal brain development and
adult physiology. This has begun to dramatically change our view of these resident …

Microglia and the brain: complementary partners in development and disease

TR Hammond, D Robinton… - Annual review of cell and …, 2018 - annualreviews.org
An explosion of findings driven by powerful new technologies has expanded our
understanding of microglia, the resident immune cells of the central nervous system (CNS) …

Microglia: key elements in neural development, plasticity, and pathology

UB Eyo, ME Dailey - Journal of Neuroimmune Pharmacology, 2013 - Springer
A century after Cajal identified a “third element” of the nervous system, many issues have
been clarified about the identity and function of one of its major components, the microglia …

Microglia: architects of the developing nervous system

JL Frost, DP Schafer - Trends in cell biology, 2016 - cell.com
Microglia are resident macrophages of the central nervous system (CNS), representing 5–
10% of total CNS cells. Recent findings reveal that microglia enter the embryonic brain, take …

Microglia as dynamic cellular mediators of brain function

EC Wright-Jin, DH Gutmann - Trends in Molecular Medicine, 2019 - cell.com
Originally hypothesized to function solely as immunologic responders within the central
nervous system (CNS), emerging evidence has revealed that microglia have more complex …

Functions of microglia in the central nervous system–beyond the immune response

H Wake, AJ Moorhouse, J Nabekura - Neuron glia biology, 2011 - cambridge.org
Microglia cells are the immune cells of the central nervous system and consequently play
important roles in brain infections and inflammation. Recent in vivo imaging studies have …

New insights into microglia–neuron interactions: a neuron's perspective

B Pósfai, C Cserép, B Orsolits, Á Dénes - Neuroscience, 2019 - Elsevier
Microglia are the primary immune cells of the central nervous system. However, recent data
indicate that microglia also contribute to diverse physiological and pathophysiological …

Microglial modulation of neuronal activity in the healthy brain

EM York, LP Bernier… - Developmental …, 2018 - Wiley Online Library
Investigations on the role of microglia in the brain have traditionally been focused on their
contributions to disease states. However, recent observations have now convincingly shown …

Microglia in brain development and regeneration

LC Mehl, AV Manjally, O Bouadi, EM Gibson… - …, 2022 - journals.biologists.com
It has recently emerged that microglia, the tissue-resident macrophages of the central
nervous system, play significant non-innate immune roles to support the development …

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

TL Tay, JC Savage, CW Hui, K Bisht… - The Journal of …, 2017 - Wiley Online Library
Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …