Amyloid precursor protein (APP) has been strongly implicated in the pathogenesis of
Alzheimer's disease (AD). Although impaired synaptic function is believed to be an early and …

Overexpression of the amyloid precursor protein (APP) in hippocampal neurons leads to
elevated β-amyloid peptide (Aβ) production and consequent depression of excitatory …

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still
poorly understood. We previously showed that GABAergic short-term plasticity is impaired in …

Alzheimer's is a crippling neurodegenerative disease that largely affects aged individuals.
Decades of research have highlighted age-related changes in calcium homeostasis that …

The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ)
peptides, key etiological agents of Alzheimer's disease (AD), are generated by sequential …

The function of the amyloid precursor protein (APP) is not fully understood, but its cleavage
product amyloid beta (Aβ) together with neurofibrillary tangles constitute the hallmarks of …

Amyloid precursor protein (APP) is associated with both familial and sporadic forms of
Alzheimer's disease. Despite its importance, the role of APP family in neuronal function and …

The relationship between altered metabolism of the amyloid-β precursor protein (APP) and
Alzheimer's disease is well established but the physiological roles of APP still remain …

The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular
synapse development and for the formation and plasticity of synapses within the CNS …

Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis.
Here we reveal that the APP plays an important role in the neural progenitor proliferation …