Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury

JYC Hsu, R McKeon, S Goussev, Z Werb… - Journal of …, 2006 - Soc Neuroscience
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury
and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first …

Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events

LJ Noble, F Donovan, T Igarashi… - Journal of …, 2002 - Soc Neuroscience
Inflammation in general and proteinases generated as a result are likely mediators of early
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …

Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord

JYC Hsu, LYW Bourguignon, CM Adams… - Journal of …, 2008 - Soc Neuroscience
In the injured spinal cord, a glial scar forms and becomes a major obstacle to axonal
regeneration. Formation of the glial scar involves migration of astrocytes toward the lesion …

Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing

S Goussev, JYC Hsu, Y Lin, T Tjoa, N Maida… - … of Neurosurgery: Spine, 2003 - thejns.org
Object. Matrix metalloproteinases (MMPs), particularly MMP-9/gelatinase B, promote early
inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs …

An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice

JEA Wells, TK Rice, RK Nuttall… - Journal of …, 2003 - Soc Neuroscience
We investigated the role of matrix metalloproteinases (MMPs) in acute spinal cord injury
(SCI). Transcripts encoding 22 of the 23 known mammalian MMPs were measured in the …

[HTML][HTML] Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury

H Zhang, M Chang, CN Hansen, DM Basso… - …, 2011 - Elsevier
This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the context
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …

[HTML][HTML] Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury

A Buss, K Pech, BA Kakulas, D Martin, J Schoenen… - BMC neurology, 2007 - Springer
Abstract Background Matrix metalloproteinases (MMPs) are a family of extracellular
endopeptidases that degrade the extracellular matrix and other extracellular proteins …

Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve

S Chattopadhyay, RR Myers, J Janes… - Brain, behavior, and …, 2007 - Elsevier
Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced in Schwann
cells hours after peripheral nerve injury and controls axonal degeneration and macrophage …

Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury

X Wang, JC Jung, M Asahi, W Chwang… - Journal of …, 2000 - Soc Neuroscience
Matrix metalloproteinases (MMPs) belong to a class of extracellular proteinases responsible
for maintaining and remodeling the extracellular matrix. In addition to multiple functions in …

Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury

KK Veeravalli, VR Dasari, AJ Tsung, DH Dinh… - Neurobiology of …, 2009 - Elsevier
Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes involved in
inflammation, wound healing and other pathological processes after neurological disorders …