Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury
JYC Hsu, R McKeon, S Goussev, Z Werb… - Journal of …, 2006 - Soc Neuroscience
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury
and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first …
and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first …
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events
LJ Noble, F Donovan, T Igarashi… - Journal of …, 2002 - Soc Neuroscience
Inflammation in general and proteinases generated as a result are likely mediators of early
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …
secondary pathogenesis after spinal cord injury. We report that matrix metalloproteinase-9 …
Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord
JYC Hsu, LYW Bourguignon, CM Adams… - Journal of …, 2008 - Soc Neuroscience
In the injured spinal cord, a glial scar forms and becomes a major obstacle to axonal
regeneration. Formation of the glial scar involves migration of astrocytes toward the lesion …
regeneration. Formation of the glial scar involves migration of astrocytes toward the lesion …
Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing
S Goussev, JYC Hsu, Y Lin, T Tjoa, N Maida… - … of Neurosurgery: Spine, 2003 - thejns.org
Object. Matrix metalloproteinases (MMPs), particularly MMP-9/gelatinase B, promote early
inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs …
inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs …
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice
JEA Wells, TK Rice, RK Nuttall… - Journal of …, 2003 - Soc Neuroscience
We investigated the role of matrix metalloproteinases (MMPs) in acute spinal cord injury
(SCI). Transcripts encoding 22 of the 23 known mammalian MMPs were measured in the …
(SCI). Transcripts encoding 22 of the 23 known mammalian MMPs were measured in the …
[HTML][HTML] Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury
This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the context
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …
of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of expression …
[HTML][HTML] Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury
A Buss, K Pech, BA Kakulas, D Martin, J Schoenen… - BMC neurology, 2007 - Springer
Abstract Background Matrix metalloproteinases (MMPs) are a family of extracellular
endopeptidases that degrade the extracellular matrix and other extracellular proteins …
endopeptidases that degrade the extracellular matrix and other extracellular proteins …
Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve
S Chattopadhyay, RR Myers, J Janes… - Brain, behavior, and …, 2007 - Elsevier
Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced in Schwann
cells hours after peripheral nerve injury and controls axonal degeneration and macrophage …
cells hours after peripheral nerve injury and controls axonal degeneration and macrophage …
Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury
X Wang, JC Jung, M Asahi, W Chwang… - Journal of …, 2000 - Soc Neuroscience
Matrix metalloproteinases (MMPs) belong to a class of extracellular proteinases responsible
for maintaining and remodeling the extracellular matrix. In addition to multiple functions in …
for maintaining and remodeling the extracellular matrix. In addition to multiple functions in …
Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury
KK Veeravalli, VR Dasari, AJ Tsung, DH Dinh… - Neurobiology of …, 2009 - Elsevier
Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes involved in
inflammation, wound healing and other pathological processes after neurological disorders …
inflammation, wound healing and other pathological processes after neurological disorders …
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