Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation

JL Warner-Schmidt, M Flajolet, A Maller… - Journal of …, 2009 - Soc Neuroscience
p11 (S100A10), a member of a large family of S100 proteins, interacts with serotonin
receptor 1B (5-HTR1B), modulates 5-HT1B receptor signal transduction, and is required for …

S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior

N Stroth, P Svenningsson - European Neuropsychopharmacology, 2015 - Elsevier
Abstract The serotonin 5-HT 7 receptor (5-HT 7) is an emerging target for psychiatric
pharmacotherapy. Recent observations in rodent models and humans suggest that its …

The 5-HT1B receptor: a novel target for the pathophysiology of depression (supplementary tables)

BM Ruf, Z Bhagwagar - Current drug targets, 2009 - ingentaconnect.com
The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …

Co-expression of serotonin 5-HT1B and 5-HT4 receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum

M Egeland, J Warner-Schmidt, P Greengard… - …, 2011 - Elsevier
p11 is an adaptor protein which binds to serotonin 5-HT1B receptors and 5-HT4 receptors
and regulates their localization at the cell surface. In the present study, we examined to what …

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

M Guscott, LJ Bristow, K Hadingham, TW Rosahl… - …, 2005 - Elsevier
The affinity of several antidepressant and antipsychotic drugs for the 5-HT7 receptor and its
CNS distribution suggest potential in the treatment of psychiatric diseases. However, there is …

[HTML][HTML] S100A10 and its binding partners in depression and antidepressant actions

MX Chen, YS Oh, Y Kim - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant
actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking …

[HTML][HTML] Cellular mechanisms of the 5-HT7 receptor-mediated signaling

D Guseva, A Wirth, E Ponimaskin - Frontiers in behavioral …, 2014 - frontiersin.org
Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter regulating a wide
range of physiological and pathological functions via activation of heterogeneously …

p11 and its role in depression and therapeutic responses to antidepressants

P Svenningsson, Y Kim, J Warner-Schmidt… - Nature Reviews …, 2013 - nature.com
Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on
the molecular and cellular mechanisms underlying depression. Here, we review data …

5-HT1A receptor function in major depressive disorder

J Savitz, I Lucki, WC Drevets - Progress in neurobiology, 2009 - Elsevier
Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Functional, molecular and pharmacological advances in 5-HT7 receptor research

PB Hedlund, JG Sutcliffe - Trends in pharmacological sciences, 2004 - cell.com
The 5-HT 7 receptor was among a group of 5-HT receptors that were discovered using
targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G …