Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis

HH Yu, JS Yang, J Wang, Y Huang… - Journal of …, 2009 - Soc Neuroscience
Drosophila Down syndrome cell adhesion molecule (Dscam) can be variably spliced to
encode 152,064 distinct single-pass transmembrane proteins. In addition to 19,008 possible …

Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization

L Shi, HH Yu, JS Yang, T Lee - Journal of Neuroscience, 2007 - Soc Neuroscience
Drosophila Dscam isoforms are derived from two alternative transmembrane/
juxtamembrane domains (TMs) in addition to thousands of ectodomain variants. Using a …

Dscam1 has diverse neuron type-specific functions in the developing Drosophila CNS

N Wilhelm, S Kumari, N Krick, C Rickert, C Duch - ENeuro, 2022 - eneuro.org
Two key features endow Drosophila Down syndrome cell adhesion molecule 1 (Dscam1)
with the potential to provide a ubiquitous code for neuronal arbor self-avoidance. First …

Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons

KM Hutchinson, F Vonhoff, C Duch - Journal of Neuroscience, 2014 - Soc Neuroscience
Down syndrome cell adhesion molecule, Dscam, serves diverse neurodevelopmental
functions, including axon guidance and synaptic adhesion, as well as self-recognition and …

DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex

L Zhang, Y Huang, JY Chen, YQ Ding, NN Song - Brain research, 2015 - Elsevier
Down syndrome cell adhesion molecule (Dscam) is essential for self-avoidance and tiling of
dendritic development in sensory neurons in Drosophila. Recent studies also show that …

[PDF][PDF] Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons

JH Kim, X Wang, R Coolon, B Ye - Neuron, 2013 - cell.com
Expression of the Down syndrome cell-adhesion molecule (Dscam) is increased in the
brains of patients with several neurological disorders. Although Dscam is critically involved …

Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition

SA Li, L Cheng, Y Yu, J Wang, Q Chen - Science Advances, 2016 - science.org
The Drosophila neural receptor Dscam1 (Down syndrome cell adhesion molecule 1) plays
an essential role in neuronal wiring and self-avoidance. Dscam1 potentially encodes 19,008 …

Molecular diversity of Dscam: recognition of molecular identity in neuronal wiring

D Schmucker - Nature Reviews Neuroscience, 2007 - nature.com
Our understanding of how the enormously complex task of interconnecting millions of nerve
cells is accomplished remains rudimentary. What molecular mechanisms control its …

Dscam mutation leads to hydrocephalus and decreased motor function

Y Xu, H Ye, Y Shen, Q Xu, L Zhu, J Liu, JY Wu - Protein & cell, 2011 - academic.oup.com
The nervous system is one of the most complicated organ systems in invertebrates and
vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) …

[HTML][HTML] The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis

D Yimlamai, L Konnikova, LG Moss, DG Jay - Developmental biology, 2005 - Elsevier
The Down syndrome cell adhesion molecule (Dscam) is a protein overexpressed in the
brains of Down syndrome patients and implicated in mental retardation. Dscam is involved …