Long-term weight management by dieting has a high failure rate. Pharmacological targets
have focused on appetite reduction, although less is understood as to the potential …

Dieting and stress are important in the etiology and maintenance of eating disorders, and
dieting strongly predicts stress-induced overeating in humans. We hypothesized that caloric …

BACKGROUND: Obesity is a modern health epidemic, with the overconsumption of highly
palatable, calorically dense foods as a likely contributor. Despite the known consequences …

Objective: To identify the emotional and motivational processes that reinstate palatable food
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …

Clinical binge eating runs a protracted course. The etiology of binge eating remains
perplexing in part because, in humans, it is difficult to isolate and assess the independent …

Obesity-induced changes in the metabolic and endocrine milieu elicit deficits in
neuroplasticity, including increased risk for development of neuropsychiatric disorders such …

A history of dieting is common in individuals suffering from eating disorders for which
depression and mood disturbances are also comorbid. We investigated the effect of a history …

Increased expression of melanin concentrating hormone (MCH), an orexigenic
neuropeptide produced by neurons in the lateral hypothalamic area (LHA), is implicated in …

Caloric restriction is a robust intervention to increase lifespan. Giving less food (calorie
restriction [CR]) or allowing free access to a diluted diet with indigestible components …

BACKGROUND: Food restriction is known to enhance learning and motivation. The neural
mechanisms underlying these responses likely involve alterations in gene expression in …