Dynorphins regulate fear memory: from mice to men
A Bilkei-Gorzo, S Erk, B Schürmann… - Journal of …, 2012 - Soc Neuroscience
Reexposure to trauma reminders is an integral element of trauma-focused cognitive
behavioral therapy (Roberts et al., 2009), but little is known about the physiological …
behavioral therapy (Roberts et al., 2009), but little is known about the physiological …
Dynorphins regulate the strength of social memory
A Bilkei-Gorzo, D Mauer, K Michel, A Zimmer - Neuropharmacology, 2014 - Elsevier
Emotionally arousing events like encounter with an unfamiliar con-species produce strong
and vivid memories, whereby the hippocampus and amygdala play a crucial role. It is less …
and vivid memories, whereby the hippocampus and amygdala play a crucial role. It is less …
Single dose of l-dopa makes extinction memories context-independent and prevents the return of fear
Traumatic events can engender persistent excessive fear responses to trauma reminders
that may return even after successful treatment. Extinction, the laboratory analog of behavior …
that may return even after successful treatment. Extinction, the laboratory analog of behavior …
Redundant catecholamine signaling consolidates fear memory via phospholipase C
M Ouyang, MB Young, MM Lestini… - Journal of …, 2012 - Soc Neuroscience
Memories for emotionally arousing experiences are typically vivid and persistent. The
recurrent, intrusive memories of traumatic events in post-traumatic stress disorder (PTSD) …
recurrent, intrusive memories of traumatic events in post-traumatic stress disorder (PTSD) …
Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice
D Yamada, S Yanagisawa, K Yoshizawa, S Yanagita… - …, 2019 - Elsevier
We reported previously that KNT-127 and SNC80, selective agonists of the δ-opioid receptor
(DOP), had potent anxiolytic-like effects in rodents. In this study, we evaluated whether KNT …
(DOP), had potent anxiolytic-like effects in rodents. In this study, we evaluated whether KNT …
[HTML][HTML] Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma
Despite the large comorbidity between PTSD and opioid use disorders, as well as the
common treatment of physical injuries resulting from trauma with opioids, the ability of opioid …
common treatment of physical injuries resulting from trauma with opioids, the ability of opioid …
[HTML][HTML] Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice
A Kawaminami, D Yamada, S Yanagisawa… - Frontiers in Behavioral …, 2022 - frontiersin.org
Facilitation of fear extinction is a desirable action for the drugs to treat fear-related diseases,
such as posttraumatic stress disorder (PTSD). We previously reported that a selective …
such as posttraumatic stress disorder (PTSD). We previously reported that a selective …
Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD
Intrusive memories resulting from an emotional trauma are a defining feature of
posttraumatic stress disorder (PTSD). Existing studies demonstrate that an increase of …
posttraumatic stress disorder (PTSD). Existing studies demonstrate that an increase of …
Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
AD Abraham, SM Casello, SS Schattauer… - …, 2021 - nature.com
Following repeated opioid use, some dependent individuals experience persistent cognitive
deficits that contribute to relapse of drug-taking behaviors, and one component of this …
deficits that contribute to relapse of drug-taking behaviors, and one component of this …
[HTML][HTML] A cFos activation map of remote fear memory attenuation
Rationale The experience of strong traumata leads to the formation of enduring fear
memories that may degenerate into post-traumatic stress disorder. One of the most …
memories that may degenerate into post-traumatic stress disorder. One of the most …