The neuroscience of placebo effects: connecting context, learning and health

TD Wager, LY Atlas - Nature Reviews Neuroscience, 2015 - nature.com
Placebo effects are beneficial effects that are attributable to the brain–mind responses to the
context in which a treatment is delivered rather than to the specific actions of the drug. They …

Placebo and the new physiology of the doctor-patient relationship

F Benedetti - Physiological reviews, 2013 - journals.physiology.org
Modern medicine has progressed in parallel with the advancement of biochemistry,
anatomy, and physiology. By using the tools of modern medicine, the physician today can …

[HTML][HTML] An fMRI-based neurologic signature of physical pain

TD Wager, LY Atlas, MA Lindquist, M Roy… - … England Journal of …, 2013 - Mass Medical Soc
Background Persistent pain is measured by means of self-report, the sole reliance on which
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …

[HTML][HTML] Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

M Zunhammer, T Spisák, TD Wager, U Bingel - Nature communications, 2021 - nature.com
The brain systems underlying placebo analgesia are insufficiently understood. Here we
performed a systematic, participant-level meta-analysis of experimental functional …

Mindfulness meditation-based pain relief employs different neural mechanisms than placebo and sham mindfulness meditation-induced analgesia

F Zeidan, NM Emerson, SR Farris, JN Ray… - Journal of …, 2015 - Soc Neuroscience
Mindfulness meditation reduces pain in experimental and clinical settings. However, it
remains unknown whether mindfulness meditation engages pain-relieving mechanisms …

[HTML][HTML] Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

RR Edwards, RH Dworkin, DC Turk, MS Angst… - Pain …, 2021 - journals.lww.com
There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

[PDF][PDF] Placebo analgesia: a predictive coding perspective

C Büchel, S Geuter, C Sprenger, F Eippert - Neuron, 2014 - cell.com
This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual
account of how expectations and experience can lead to placebo hypoalgesia. In particular …

Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice

M Schedlowski, P Enck, W Rief, U Bingel - Pharmacological reviews, 2015 - ASPET
The placebo effect has often been considered a nuisance in basic and particularly clinical
research. This view has gradually changed in recent years due to deeper insight into the …

The placebo effect: from concepts to genes

B Colagiuri, LA Schenk, MD Kessler, SG Dorsey… - Neuroscience, 2015 - Elsevier
Despite its initial treatment as a nuisance variable, the placebo effect is now recognized as a
powerful determinant of health across many different diseases and encounters. This is in …

[PDF][PDF] Placebo effects: from the neurobiological paradigm to translational implications

F Benedetti - Neuron, 2014 - cell.com
Today we are witnessing a new science of placebo, a complex discipline that encompasses
several experimental approaches and translational implications. Modern neurobiological …