Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Ageing is accompanied by an inexorable loss of muscle mass and functionality and
represents a major risk factor for numerous diseases such as cancer, diabetes and …

Key points Few days of unloading are sufficient to induce a decline of skeletal muscle mass
and function; notably, contractile force is lost at a faster rate than muscle mass. The reasons …

Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction
(NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) …

Although, the nucleolus has been observed for almost 200 years in neurons, studies that
directly address the neuronal roles of this subnuclear structure have appeared only recently …

Background Ageing is accompanied by a progressive loss of skeletal muscle mass and
strength, potentially determining the insurgence of sarcopenia. Evidence suggests that …

LM Murray, K. Talbot and TH Gillingwater (2010) Neuropathology and Applied
Neurobiology36, 133–156 Neuromuscular synaptic vulnerability in motor neurone disease …

Excessive synapses generated during early development are eliminated extensively to form
functionally mature neural circuits. Synapses in juvenile and mature brains are highly …

The identity of muscle secreted factors critical for the development and maintenance of
neuromuscular junctions (NMJs) remains largely unknown. Here, we show that muscle …

Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well
established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key …