Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

Recent genome-wide association studies indicate that a simple alteration of Leucine-rich
repeat kinase 2 (LRRK2) gene expression may contribute to the etiology of sporadic …

Voluntary movement is a fundamental way in which animals respond to, and interact with,
their environment. In mammals, the main CNS pathway controlling voluntary movement is …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects
motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been …

Neurodegenerative diseases are amongst the most devastating of human disorders. New
technologies have led to a rapid increase in the identification of disease-related genes with …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results
in loss of the upper and lower motor neurons from motor cortex, brainstem, and spinal cord …

Glutamate, the major excitatory neurotransmitter in the CNS, is implicated in both normal
neurotransmission and excitotoxicity. Numerous in vitro findings indicate that the ionotropic …