Metals in neurobiology: probing their chemistry and biology with molecular imaging

EL Que, DW Domaille, CJ Chang - Chemical reviews, 2008 - ACS Publications
The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

Prion diseases of humans and animals: their causes and molecular basis

J Collinge - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …

[HTML][HTML] The biological function of the cellular prion protein: an update

MA Wulf, A Senatore, A Aguzzi - BMC biology, 2017 - Springer
The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

Signal transduction through prion protein

S Mouillet-Richard, M Ermonval, C Chebassier… - Science, 2000 - science.org
The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface
protein whose biological function is unclear. We used the murine 1C11 neuronal …

Physiology of the prion protein

R Linden, VR Martins, MAM Prado… - Physiological …, 2008 - journals.physiology.org
Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

[HTML][HTML] PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

GT Corbett, Z Wang, W Hong, M Colom-Cadena… - Acta …, 2020 - Springer
Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

JH Viles - Coordination Chemistry Reviews, 2012 - Elsevier
There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

[HTML][HTML] The cellular prion protein (PrPC): its physiological function and role in disease

L Westergard, HM Christensen, DA Harris - Biochimica et Biophysica Acta …, 2007 - Elsevier
Prion diseases are caused by conversion of a normal cell-surface glycoprotein (PrPC) into a
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …

Insights into prion strains and neurotoxicity

A Aguzzi, M Heikenwalder… - Nature reviews Molecular …, 2007 - nature.com
Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …

Imaging Amyloid‐β Membrane Interactions: Ion‐Channel Pores and Lipid‐Bilayer Permeability in Alzheimer's Disease

JH Viles - Angewandte Chemie, 2023 - Wiley Online Library
The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …