Metals in neurobiology: probing their chemistry and biology with molecular imaging
The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …
center for cognitive and motor function. As such, this specialized system also possesses a …
Prion diseases of humans and animals: their causes and molecular basis
J Collinge - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …
[HTML][HTML] The biological function of the cellular prion protein: an update
MA Wulf, A Senatore, A Aguzzi - BMC biology, 2017 - Springer
The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
Signal transduction through prion protein
S Mouillet-Richard, M Ermonval, C Chebassier… - Science, 2000 - science.org
The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface
protein whose biological function is unclear. We used the murine 1C11 neuronal …
protein whose biological function is unclear. We used the murine 1C11 neuronal …
Physiology of the prion protein
Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
[HTML][HTML] PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …
millions of people worldwide. Nearly all of these diseases are characterized by …
Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
JH Viles - Coordination Chemistry Reviews, 2012 - Elsevier
There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …
amyloid fibers. Many of these diseases have a major impact on human health, in particular …
[HTML][HTML] The cellular prion protein (PrPC): its physiological function and role in disease
L Westergard, HM Christensen, DA Harris - Biochimica et Biophysica Acta …, 2007 - Elsevier
Prion diseases are caused by conversion of a normal cell-surface glycoprotein (PrPC) into a
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …
Insights into prion strains and neurotoxicity
A Aguzzi, M Heikenwalder… - Nature reviews Molecular …, 2007 - nature.com
Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …
are caused by prions and affect humans and many animal species. It is now widely accepted …
Imaging Amyloid‐β Membrane Interactions: Ion‐Channel Pores and Lipid‐Bilayer Permeability in Alzheimer's Disease
JH Viles - Angewandte Chemie, 2023 - Wiley Online Library
The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …