We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Despite advances towards understanding the molecular pathophysiology of the
neurodegenerative dementias, the mechanisms linking molecular changes to neuropathology and …

The most widely established diagnostic criteria for the behavioral variant of frontotemporal
dementia have now been in use for almost a decade. Although consensus criteria have …

Variations in neural circuitry, inherited or acquired, may underlie important individual differences
in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to …

Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …

Based on the recent literature and collective experience, an international consortium developed
revised guidelines for the diagnosis of behavioural variant frontotemporal dementia. The …

During development, the healthy human brain constructs a host of large-scale, distributed,
function-critical neural networks. Neurodegenerative diseases have been thought to target …

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Resting-state or intrinsic connectivity network functional magnetic resonance imaging provides
a new tool for mapping large-scale neural network function and dysfunction. Recently, we …

Prion-like propagation of tau aggregation might underlie the stereotyped progression of
neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in …