Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease
characterized by life threatening arrhythmias and mutations in the gene encoding the ryanodine …

… Most of the disease-associated CaM mutations studied to date seem to reduce CaM’s … 2+
, from a low resting level (~1/s/100 µm in normal mouse ventricular myocytes) to much greater …

Background— A hallmark of heart failure is impaired cytoplasmic Ca 2+ handling of
cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca 2+ handling via …

… Defective calcium handling is a key contributor to the pathophysiology of heart failure, not
only in the weakening of the heart’s ability to pump blood but also in the erratic heart beats that …

… that the ultrastructural alteration in the RyR2 R420Q channel 44 alters its gating properties
even though it still remains unclear how a mutation in the NTD can alter the channel’s …

… muscle sarcoplasmic reticulum (SR) with recombinant [ 35 S]FKBP12.6, we found that the
sulfydryl-… Co-sedimentation experiments of cardiac SR vesicles with [ 35 S]FKBP12.6 also …

… Due to the controversy with regard to the precise identity of the FKBP-binding site on the
RyR, we undertook a strategy to indirectly identify the FKBP12.6 interaction site(s) on RyR2 …

… -vitro-synthesised [ 35 S]FKBP12 and [ 35 S]FKBP12.6 in the … S]FKBP12 and [ 35 S]FKBP12.6.
Pig cardiac SR vesicles were incubated with in-vitro-synthesised [ 35 S]FKBP12 and [ 35 S]…

… The RyR was purified from skeletal and cardiac muscle using [ 3 H]–ryanodine as a
selective marker and found to exist in a tetrameric form that sediments as a very large (30 S) …

… Elucidation of the CSQ2-binding site within the first luminal loop of RyR2 should help in
further understanding the pathologic mechanism(s) underlying arrhythmias and sudden cardiac …