Recognition ligands on apoptotic cells: a perspective

SJ Gardai, DL Bratton, CA Ogden… - Journal of leukocyte …, 2006 - academic.oup.com
The process of apoptosis includes critically important changes on the cell surface that lead
to its recognition and removal. The recognition also generates a number of other local tissue …

[PDF][PDF] Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

SJ Gardai, KA McPhillips, SC Frasch, WJ Janssen… - Cell, 2005 - cell.com
Apoptotic-cell removal is critical for development, tissue homeostasis, and resolution of
inflammation. Although many candidate systems exist, only phosphatidylserine has been …

[HTML][HTML] By binding SIRPα or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation

SJ Gardai, YQ Xiao, M Dickinson, JA Nick, DR Voelker… - Cell, 2003 - cell.com
Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions,
a globular head domain that binds PAMPs and a collagenous tail domain that initiates …

[HTML][HTML] × Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils

SJ Gardai, DA Hildeman, SK Frankel… - Journal of Biological …, 2004 - ASBMB
Although important for apoptosis, the mechanism of Bax regulation is poorly understood.
This study demonstrates that phosphorylation of Ser 184 regulates Bax activity. The …

[HTML][HTML] Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in …

CG Freire-de-Lima, YQ Xiao, SJ Gardai… - Journal of Biological …, 2006 - ASBMB
Apoptotic cells are rapidly engulfed by adjacent tissue cells or macrophages before they can
release pro-inflammatory/proimmunogenic intracellular contents. In addition, recognition of …

Peroxisome proliferator-activated receptor gamma (PPARγ) expression is decreased in pulmonary hypertension and affects endothelial cell growth

…, CD Cool, D Chan, RW Vandivier, SJ Gardai… - Circulation …, 2003 - Am Heart Assoc
PPARγ is a member of a family of nuclear receptors/ligand–dependent transcription factors,
which bind to hormone response elements on target gene promoters. An antiproliferative …

Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRPα

…, RW Vandivier, PM Henson, SJ Gardai - American journal of …, 2008 - atsjournals.org
Rationale: Efficient removal of apoptotic cells is essential for the resolution of acute
pulmonary inflammation. Alveolar macrophages ingest apoptotic cells less avidly than other …

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

AW Jehle, SJ Gardai, S Li, P Linsel-Nitschke… - The Journal of cell …, 2006 - rupress.org
The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 and -A7) show
sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the clearance of …

[HTML][HTML] Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

G Toth, SJ Gardai, W Zago, CW Bertoncini… - PloS one, 2014 - journals.plos.org
The misfolding of intrinsically disordered proteins such as α-synuclein, tau and the Aβ
peptide has been associated with many highly debilitating neurodegenerative syndromes …

[HTML][HTML] Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease

SJ Gardai, W Mao, B Schüle, M Babcock, S Schoebel… - PloS one, 2013 - journals.plos.org
Alpha-synuclein protein is strongly implicated in the pathogenesis Parkinson's disease.
Increased expression of α-synuclein due to genetic multiplication or point mutations leads to …