PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors
In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona
occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] …
occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] …
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat
Background and Purpose— Postsynaptic density-95 inhibitors reduce ischemic brain damage
without inhibiting excitatory neurotransmission, circumventing the negative consequences …
without inhibiting excitatory neurotransmission, circumventing the negative consequences …
[HTML][HTML] Prefrontal ischemia in the rat leads to secondary damage and inflammation in remote gray and white matter regions
N Weishaupt, A Zhang, RA Deziel, RA Tasker… - Frontiers in …, 2016 - frontiersin.org
Secondary damage processes, such as inflammation and oxidative stress, can exacerbate
an ischemic lesion and spread to adjacent brain regions. Yet, few studies investigate how …
an ischemic lesion and spread to adjacent brain regions. Yet, few studies investigate how …
Low doses of domoic acid during postnatal development produce permanent changes in rat behaviour and hippocampal morphology
It is well established that the developing brain is a highly dynamic environment that is
susceptible to toxicity produced by a number of pharmacological, chemical and environmental …
susceptible to toxicity produced by a number of pharmacological, chemical and environmental …
Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats
…, PJ Gebicke-Haerter, M Morelli, RA Tasker… - Experimental brain …, 2010 - Springer
There is no established treatment for the long-term effects produced by perinatal asphyxia.
Thus, we investigated the neuroprotection provided by nicotinamide against the effects …
Thus, we investigated the neuroprotection provided by nicotinamide against the effects …
Development of a mist-based printhead for droplet-based bioprinting of ionically crosslinking hydrogel bioinks
…, E Naseri, D MacDonald, A Bodaghkhani, RA Tasker… - Bioprinting, 2022 - Elsevier
In this paper, a novel droplet-based printhead is developed for 3D bioprinting of ionically
crosslinking hydrogel bioinks. Contrary to previous approaches to droplet-based bioprinting, …
crosslinking hydrogel bioinks. Contrary to previous approaches to droplet-based bioprinting, …
Development of foam-based support material for coaxial bioprinting of ionically crosslinking bioinks
E Madadian, S Badr, DS MacDonald, RA Tasker… - Bioprinting, 2023 - Elsevier
In this study, a foam-based method is developed for three-dimensional coaxial bioprinting of
ionically crosslinking bioinks. This method introduces the crosslinker to the bioink in calcium …
ionically crosslinking bioinks. This method introduces the crosslinker to the bioink in calcium …
Investigation of rheology, printability, and biocompatibility of N, O-carboxymethyl chitosan and agarose bioinks for 3D bioprinting of neuron cells
HM Butler, E Naseri, DS MacDonald, RA Tasker… - Materialia, 2021 - Elsevier
This paper investigates the suitability of varying compositions of N,O-Carboxymethyl Chitosan
(NOCC) and agarose blend bioinks for 3D bioprinting. The bioinks encapsulating neuro2A …
(NOCC) and agarose blend bioinks for 3D bioprinting. The bioinks encapsulating neuro2A …
Ischemic lesions localized to the medial prefrontal cortex produce selective deficits in measures of executive function in rats
Ischemic stroke is one of the leading causes of neurological disability worldwide, and it has
been estimated that about one quarter of stroke survivors experience some measurable long-…
been estimated that about one quarter of stroke survivors experience some measurable long-…
Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development
…, DS MacDonald, DA Gill, CL Ryan, RA Tasker - …, 2007 - Wiley Online Library
We have previously reported that serial systemic injections of low‐dose (subconvulsive) domoic
acid (DOM) during early postnatal development produces changes in both behavior and …
acid (DOM) during early postnatal development produces changes in both behavior and …