PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors

…, MW Salter, YT Wang, RA Tasker… - Journal of …, 2007 - Soc Neuroscience
In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona
occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] …

Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat

…, A Lau, JP Forder, MW Salter, YT Wang, RA Tasker… - Stroke, 2008 - Am Heart Assoc
Background and Purpose— Postsynaptic density-95 inhibitors reduce ischemic brain damage
without inhibiting excitatory neurotransmission, circumventing the negative consequences …

[HTML][HTML] Prefrontal ischemia in the rat leads to secondary damage and inflammation in remote gray and white matter regions

N Weishaupt, A Zhang, RA Deziel, RA Tasker… - Frontiers in …, 2016 - frontiersin.org
Secondary damage processes, such as inflammation and oxidative stress, can exacerbate
an ischemic lesion and spread to adjacent brain regions. Yet, few studies investigate how …

Low doses of domoic acid during postnatal development produce permanent changes in rat behaviour and hippocampal morphology

…, H Husum, MA Perry, CL Ryan, RA Tasker - Neurotoxicity …, 2004 - Springer
It is well established that the developing brain is a highly dynamic environment that is
susceptible to toxicity produced by a number of pharmacological, chemical and environmental …

Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats

…, PJ Gebicke-Haerter, M Morelli, RA Tasker… - Experimental brain …, 2010 - Springer
There is no established treatment for the long-term effects produced by perinatal asphyxia.
Thus, we investigated the neuroprotection provided by nicotinamide against the effects …

Development of a mist-based printhead for droplet-based bioprinting of ionically crosslinking hydrogel bioinks

…, E Naseri, D MacDonald, A Bodaghkhani, RA Tasker… - Bioprinting, 2022 - Elsevier
In this paper, a novel droplet-based printhead is developed for 3D bioprinting of ionically
crosslinking hydrogel bioinks. Contrary to previous approaches to droplet-based bioprinting, …

Development of foam-based support material for coaxial bioprinting of ionically crosslinking bioinks

E Madadian, S Badr, DS MacDonald, RA Tasker… - Bioprinting, 2023 - Elsevier
In this study, a foam-based method is developed for three-dimensional coaxial bioprinting of
ionically crosslinking bioinks. This method introduces the crosslinker to the bioink in calcium …

Investigation of rheology, printability, and biocompatibility of N, O-carboxymethyl chitosan and agarose bioinks for 3D bioprinting of neuron cells

HM Butler, E Naseri, DS MacDonald, RA Tasker… - Materialia, 2021 - Elsevier
This paper investigates the suitability of varying compositions of N,O-Carboxymethyl Chitosan
(NOCC) and agarose blend bioinks for 3D bioprinting. The bioinks encapsulating neuro2A …

Ischemic lesions localized to the medial prefrontal cortex produce selective deficits in measures of executive function in rats

RA Déziel, CL Ryan, RA Tasker - Behavioural brain research, 2015 - Elsevier
Ischemic stroke is one of the leading causes of neurological disability worldwide, and it has
been estimated that about one quarter of stroke survivors experience some measurable long-…

Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development

…, DS MacDonald, DA Gill, CL Ryan, RA Tasker - …, 2007 - Wiley Online Library
We have previously reported that serial systemic injections of low‐dose (subconvulsive) domoic
acid (DOM) during early postnatal development produces changes in both behavior and …