User profiles for M. N. Gordon
Marcia N. Gordon, PhDMichigan State University Verified email at hc.msu.edu Cited by 17811 |
Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
The presence of activated microglia in postmortem Alzheimer disease specimens is used to
support the argument that inflammation contributes to Alzheimer pathogenesis. Transgenic …
support the argument that inflammation contributes to Alzheimer pathogenesis. Transgenic …
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
MUTATIONS in the genes encoding amyloid-β precursor protein (APP) 1 presenilin 1 (PS1)
2 and presenilin 2 (PS2) 3,4 are known to cause early-onset, autosomal dominant …
2 and presenilin 2 (PS2) 3,4 are known to cause early-onset, autosomal dominant …
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
L Holcomb, MN Gordon, E McGowan, X Yu… - Nature medicine, 1998 - nature.com
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor
protein (APP), presenilin 1 (PS1), and presenilin 2 (P52) genes 1 . The mutant APP K670N,…
protein (APP), presenilin 1 (PS1), and presenilin 2 (P52) genes 1 . The mutant APP K670N,…
Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease
The morphological plasticity of microglia has fascinated neuroscientists for 100 years.
Attempts to classify functional phenotypes are hampered by similarities between endogenous …
Attempts to classify functional phenotypes are hampered by similarities between endogenous …
Impact of COVID‐19 on the onset and progression of Alzheimer's disease and related dementias: a roadmap for future research
COVID‐19 causes lasting neurological symptoms in some survivors. Like other infections,
COVID‐19 may increase risk of cognitive impairment. This perspective highlights four …
COVID‐19 may increase risk of cognitive impairment. This perspective highlights four …
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
… Immunocytochemistry was performed on floating sections in 24-well plates as described
by Gordon et al. (1997). The primary antiserum was raised against AB1-40 in rabbits and …
by Gordon et al. (1997). The primary antiserum was raised against AB1-40 in rabbits and …
[HTML][HTML] Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased …
…, S Subbarao, MJ Freeman, MN Gordon… - Journal of …, 2004 - Springer
Background Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact
amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. …
amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. …
Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
This study provides a comprehensive behavioral characterization during aging of transgenic
mice bearing both presenilin-1 (PS1) and amyloid precursor protein (APP 670,671 ) …
mice bearing both presenilin-1 (PS1) and amyloid precursor protein (APP 670,671 ) …
Microglial activation and β-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus …
3-4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy
butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the …
butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the …
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
NV Patel, MN Gordon, KE Connor, RA Good… - Neurobiology of …, 2005 - Elsevier
Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging
processes are attenuated in laboratory mammals by caloric restriction (CR), we examined …
processes are attenuated in laboratory mammals by caloric restriction (CR), we examined …