User profiles for L. Porrino

LInda Porrino

Professor of physiology and pharmacology, Wake Forest school of medicine
Verified email at wakehealth.edu
Cited by 12426

Cannabinoid physiology and pharmacology: 30 years of progress

…, SA Deadwyler, RE Hampson, LJ Porrino - …, 2004 - Elsevier
Δ 9 -Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through …

Behavioral neurobiology of alcohol addiction: recent advances and challenges

F Weiss, LJ Porrino - Journal of Neuroscience, 2002 - Soc Neuroscience
… Overactivity of L-type calcium channels is a possible mechanism for the suppression of
DA release during ethanol withdrawal, because pharmacological inhibition of L-type calcium …

The effects of cocaine: a shifting target over the course of addiction

LJ Porrino, HR Smith, MA Nader… - Progress in Neuro …, 2007 - Elsevier
Repeated exposure to psychostimulant drugs such as cocaine has been shown in numerous
studies to produce significant neuroadaptations in both structure and function throughout …

The primate mediodorsal (MD) nucleus and its projection to the frontal lobe

PS Goldman‐Rakic, LJ Porrino - Journal of Comparative …, 1985 - Wiley Online Library
… Following injections in the anterior cortex surrounding the frontal pole (case #l), the medial
orbital cortex (case #2), and the inferior convexity (case #3), labeled somata were present in …

Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys

LJ Porrino, AM Crane… - Journal of Comparative …, 1981 - Wiley Online Library
To elucidate the anatomical relationships between the frontal association cortex and the
limbic system in primates, projections from the amygdala to frontal cortex were studied in the …

Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors.

ST Young, LJ Porrino… - Proceedings of the …, 1991 - National Acad Sciences
The protooncogene c-fos produces a phosphoprotein, Fos, which regulates gene transcription
processes. In neuronal systems, Fos has been proposed to couple synaptic transmission …

A naturalistic assessment of the motor activity of hyperactive boys: I. Comparison with normal controls

LJ Porrino, JL Rapoport, D Behar… - Archives of General …, 1983 - jamanetwork.com
• The motor activity of hyperactive and normal boys was studied in 12 age- and classroom-matched
pairs. Activity was measured continuously for a one-week period with a portable solid…

Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP

LJ Porrino, PS Goldman‐Rakic - Journal of Comparative …, 1982 - Wiley Online Library
… After craniectomy, the cortex was exposed and injections of 20-50% HRP (Sigma, Type VI)
were made under direct visual guidance as described previously (Porrino et al., '81). …

Long-term heavy marijuana users make costly decisions on a gambling task

…, CM Lamborn, PJ Laurienti, LJ Porrino - Drug and alcohol …, 2004 - Elsevier
Rationale: Chronic marijuana use has been associated with impairments of learning, memory,
and executive functions. Little is known, however, about the effects of marijuana use on …

Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains

LJ Porrino, D Lyons, HR Smith, JB Daunais… - Journal of …, 2004 - Soc Neuroscience
The primate striatum is composed of limbic, cognitive, and sensorimotor functional domains.
Although the effects of cocaine have generally been associated with the ventral striatum, or …