Did you mean: L. A. Strand

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

PM Grace, KA Strand, EL Galer… - Proceedings of the …, 2016 - National Acad Sciences
Opioid use for pain management has dramatically increased, with little assessment of potential
pathophysiological consequences for the primary pain condition. Here, a short course of …

Opioid activation of toll-like receptor 4 contributes to drug reinforcement

…, T Maslanik, TR Chapman, KA Strand… - Journal of …, 2012 - Soc Neuroscience
Opioid action was thought to exert reinforcing effects solely via the initial agonism of opioid
receptors. Here, we present evidence for an additional novel contributor to opioid reward: the …

Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling

AJ Jolly, S Lu, KA Strand, AM Dubner… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases are characterized by chronic vascular dysfunction and provoke
pathological remodelling events, such as neointima formation, atherosclerotic lesion …

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

…, FR Taylor, JL Wiesler, JA Babb, KA Strand… - …, 2012 - Elsevier
… First-strand cDNA was synthesized by adding 2 μl of oligo dT, 1 μl of dNTP, and 7.8 μl of
nuclease-free water to the cell lysate and incubating at 70 C for 5 min. After 2 min on ice, 6 μl of …

Prior voluntary wheel running attenuates neuropathic pain

…, SM Green-Fulgham, ND Anderson, KA Strand… - Pain, 2016 - journals.lww.com
Exercise is known to exert a systemic anti-inflammatory influence, but whether its effects are
sufficient to protect against subsequent neuropathic pain is underinvestigated. We report …

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

PM Grace, X Wang, KA Strand, MV Baratta… - Experimental …, 2018 - Elsevier
The absence of selective pharmacological tools is a major barrier to the in vivo study of
microglia. To address this issue, we developed a G q - and G i -coupled Designer Receptor …

[HTML][HTML] Redistribution of the chromatin remodeler Brg1 directs smooth muscle–derived adventitial progenitor–to–myofibroblast differentiation and vascular fibrosis

AJ Jolly, S Lu, AM Dubner, KA Strand, MF Mutryn… - JCI insight, 2023 - ncbi.nlm.nih.gov
… Ribo-depleted libraries were constructed using a SMARTer Stranded Total RNA-Seq kit (Clontech)
customized with mouse-specific oligonucleotides for rRNA removal. Directional …

Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and …

…, MT Lewis, KN Morgan, JL Kroll, FR Taylor, KA Strand… - Neuroscience, 2014 - Elsevier
CNS immune signaling contributes to deleterious opioid effects including hyperalgesia,
tolerance, reward, and dependence/withdrawal. Such effects are mediated by opioid signaling at …

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats

PM Grace, KA Strand, EL Galer, KC Rice… - Brain, behavior, and …, 2018 - Elsevier
We have recently reported that a short course of morphine, starting 10 days after sciatic chronic
constriction injury (CCI), prolonged the duration of mechanical allodynia for months after …

[HTML][HTML] Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain

…, PM Grace, MN Pham, K Cheng, KA Strand… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Rifampin has been used for the treatment of bacterial infections for many years. Clinically,
rifampin has been found to possess immunomodulatory effects. However, the molecular target …
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