Folic acid and homocysteine in age-related disease

MP Mattson, II Kruman, W Duan - Ageing research reviews, 2002 - Elsevier
It has been known for decades that babies born to women that have a dietary deficiency in
folic acid (folate) are at increased risk for birth defects, and that the nervous system is …

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

II Kruman, C Culmsee, SL Chan, Y Kruman… - Journal of …, 2000 - Soc Neuroscience
Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk
for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying mechanisms …

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's …

II Kruman, TS Kumaravel, A Lohani… - Journal of …, 2002 - Soc Neuroscience
Recent epidemiological and clinical data suggest that persons with low folic acid levels and
elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the …

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

…, B Ladenheim, RG Cutler, II Kruman… - Journal of …, 2002 - Wiley Online Library
Although the cause of Parkinson's disease (PD) is unknown, data suggest roles for environmental
factors that may sensitize dopaminergic neurons to age‐related dysfunction and death…

Why do neurons enter the cell cycle?

II Kruman - Cell cycle, 2004 - Taylor & Francis
… Defective TCR may lead to the arrest of RNA polymerase II translocation, p53 activation
and apoptosis, especially if transcription blocking DNA damage occurs in genes encoding …

HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress

II Kruman, A Nath, MP Mattson - Experimental neurology, 1998 - Elsevier
Patients infected with HIV-1 often exhibit cognitive deficits that are related to progressive
neuronal degeneration and cell death. The protein Tat, which is released from HIV-1-infected …

[HTML][HTML] Cell cycle activation linked to neuronal cell death initiated by DNA damage

II Kruman, RP Wersto, F Cardozo-Pelaez, L Smilenov… - Neuron, 2004 - cell.com
Increasing evidence indicates that neurodegeneration involves the activation of the cell
cycle machinery in postmitotic neurons. However, the purpose of these cell cycle-associated …

Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis

II Kruman, MP Mattson - Journal of neurochemistry, 1999 - Wiley Online Library
: Perturbed cellular calcium homeostasis has been implicated in both apoptosis and necrosis,
but the role of altered mitochondrial calcium handling in the cell death process is unclear. …

ALS-linked Cu/Zn–SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium …

II Kruman, WA Pedersen, JE Springer… - Experimental neurology, 1999 - Elsevier
We employed a mouse model of ALS, in which overexpression of a familial ALS-linked Cu/Zn–SOD
mutation leads to progressive MN loss and a clinical phenotype remarkably similar …

DNA damage and neurotoxicity of chronic alcohol abuse

II Kruman, GI Henderson… - … Biology and Medicine, 2012 - journals.sagepub.com
Chronic alcohol abuse results in a variety of pathological effects including damage to the
brain. The causes of alcohol-induced brain pathology are presently unclear. Several …