The ATP-dependent molecular chaperone Hsp90 is an essential and abundant stress protein
in the eukaryotic cytosol that cooperates with a cohort of cofactors/cochaperones to fulfill …

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to
proteins that contain them and cause at least nine neurological disorders. The basis for this …

Huntington disease (HD) is caused by an expansion of more than 35–40 polyglutamine (polyQ)
repeats in the huntingtin (htt) protein, resulting in accumulation of inclusion bodies …

Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-modifying
treatments available. The disease is caused by expansion of a CAG trinucleotide …

… However, a recent study indicated Hsp70 and Hsp40 can also partition onto SDS-soluble
mutant htt oligomers in an ATP-dependent manner (GP Lotz, J. Legleiter, E. Mitchell, S.-…

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a
polyglutamine (polyQ) domain in the N-terminal region of huntingtin (htt). PolyQ expansion …

A common pathological hallmark in many neurodegenerative diseases, including Alzheimer’s
disease, Parkinson’s disease, and Huntington’s disease, is the formation of fibrillar protein …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the
amplification of a polyglutamine stretch at the N terminus of the huntingtin protein. N-terminal …

Inclusion bodies of aggregated mutant huntingtin (htt) fragments are a neuropathological
hallmark of Huntington disease (HD). The molecular chaperones Hsp70 and Hsp40 colocalize …

The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on
27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an …