Resetting central and peripheral circadian oscillators in transgenic rats

…, M Abe, A Hida, R Takahashi, M Ueda, GD Block… - Science, 2000 - science.org
In multicellular organisms, circadian oscillators are organized into multitissue systems
which function as biological clocks that regulate the activities of the organism in relation to …

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically …

GD Block, J Locker, WC Bowen, BE Petersen… - The Journal of cell …, 1996 - rupress.org
Mature adult parenchymal hepatocytes, typically of restricted capacity to proliferate in culture,
can now enter into clonal growth under the influence of hepatocyte growth factor (scatter …

Circadian rhythms in isolated brain regions

…, H Tei, Y Sakaki, M Menaker, GD Block - Journal of …, 2002 - Soc Neuroscience
The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus has been referred to
as the master circadian pacemaker that drives daily rhythms in behavior and physiology. …

Association of acetaminophen hepatotoxicity with fasting and ethanol use

DC Whitcomb, GD Block - Jama, 1994 - jamanetwork.com
Objectives. —To evaluate the association of fasting and alcohol use with hepatotoxicity from
acetaminophen ingested for therapeutic reasons. Design. —Retrospective case series. …

[PDF][PDF] Chronic jet-lag increases mortality in aged mice

…, J Daniel, S Yamazaki, M Menaker, GD Block - Current biology, 2006 - cell.com
Despite the fact that trans-meridian travel and shift work are commonplace in our 24/7 society,
few controlled studies have addressed the health effects of repeated phase shifts of the …

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

ED Herzog, JS Takahashi, GD Block - Nature neuroscience, 1998 - nature.com
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker in mammals, and one
molecular regulator of circadian rhythms is the Clock gene. Here we studied the discharge …

Age-related decline in circadian output

…, T Kudo, T Cutler, CS Colwell, GD Block - Journal of …, 2011 - Soc Neuroscience
Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and
fragmentation of the sleep episodes, are commonly associated with aging in humans and …

[HTML][HTML] A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock

H Albus, MJ Vansteensel, S Michel, GD Block… - Current Biology, 2005 - cell.com
Background: Circadian rhythms in mammalian behavior, physiology, and biochemistry are
controlled by the central clock of the suprachiasmatic nucleus (SCN). The clock is …

Effects of aging on central and peripheral mammalian clocks

…, Y Sakaki, M Menaker, GD Block - Proceedings of the …, 2002 - National Acad Sciences
Circadian organization changes with age, but we do not know the extent to which age-related
changes are the result of alterations in the central pacemakers, the peripheral oscillators, …

Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction

JE Gale, HI Cox, J Qian, GD Block… - Journal of biological …, 2011 - journals.sagepub.com
Type 2 diabetes mellitus (T2DM) is complex metabolic disease that arises as a consequence
of interactions between genetic predisposition and environmental triggers. One recently …