In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic
recommendations for the preclinical, mild cognitive impairment, and dementia stages of …

The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about
the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

… Boxed areas 1 and 2 are shown at higher magnification in e and f respectively. Scale
bars in ad, 200 pum. In e, the outer molecular layer of the dentate gyrus contained areas of …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

To elucidate the role of the synaptic protein α-synuclein in neurodegenerative disorders,
transgenic mice expressing wild-type human α-synuclein were generated. Neuronal expression …

A consensus panel from the United States and Europe was convened recently to update
and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's …

… 5E). No plaques were detected in nontransgenic mice at 2–27 months of age (n = 84). … )
and imaged by laser scanning confocal microscopy (E,F). Hippocampal sections of transgenic …

Ubiquitin-positive, tau- and α-synuclein–negative inclusions are hallmarks of frontotemporal
lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. …

We present a practical guide for the implementation of recently revised National Institute on
Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’…