Members of the metzincin family of metalloproteinases have long been considered merely
degradative enzymes for extracellular matrix molecules. Recently, however, there has been …

Recellularization of whole decellularized lung scaffolds provides a novel approach for
generating functional lung tissue ex vivo for subsequent clinical transplantation. To explore the …

Several different detergent-based methods are currently being explored for de-cellularizing
whole lungs for subsequent use as three-dimensional scaffolds for ex vivo lung tissue …

Rationale: Myocardial infarction (MI) results in remodeling of the myocardium and the extracellular
matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) are critical regulators of …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

Background— Remodeling of the extracellular matrix (ECM) is a key aspect of myocardial
response to biomechanical stress and heart failure. Tissue inhibitors of metalloproteinases (…

Pulmonary diseases represent a large portion of neonatal and adult morbidity and mortality.
Many of these have no cure, and new therapeutic approaches are desperately needed. De-…

… TIMP-2 -/- mice are deficient in the acquisition of fear-potentiated startle, a model of synaptic
plasticity in the amygdala (DM Jaworski and WA Falls, unpublished observation). Whether …

Acetate, the shortest chain fatty acid, has been implicated in providing health benefits whether
it is derived from the diet or is generated from microbial fermentation of fiber in the gut. …

… )/brevican gene, which encodes an extracellular hyaluronan-binding protein, is consistently
expressed by human glioma and is not expressed by tumors of nonglial origin ( Jaworski et al…