The vast majority (> 95%) of single‐gene mutations in yeast affect not only the expression of
the mutant gene, but also the expression of many other genes. These data suggest the …

Most intercellular glutamate signaling in the nervous system occurs at synapses. Some
intercellular glutamate signaling occurs outside synapses, however, and even outside the …

Many neuroscientists assume that ambient extracellular glutamate concentrations in the
nervous system are biologically negligible under nonpathological conditions. This assumption is …

… However, this small decrease in the number of vesicles close to release sites is unlikely to
… in active zone size and number do not explain the dramatic decrease in mEJP frequency. …

We hypothesized that cystine/glutamate transporters (xCTs) might be critical regulators of
ambient extracellular glutamate levels in the nervous system and that misregulation of this …

… , 2005); and (3) GluRIIA and GluRIIB are differentially trafficked and stabilized (Chen and
Featherstone, 2005) (K. Chen, F. Liebl, and DE Featherstone unpublished data). If GluRIIA and …

Mate choice is an evolutionarily critical decision that requires the detection of multiple sex-specific
signals followed by central integration of these signals to direct appropriate behavior. …

Background Drosophila discs-large (DLG) is the sole representative of a large class of
mammalian MAGUKs, including human DLG, SAP 97, SAP102, and PSD-95. MAGUKs are …

… Although the fast-inactivation-removed Skml mutant appears to slowinactivate completely
within 1 min at potentials more depolarized than --50 mV, Skml WT often (but not always) fails …

We hypothesized that presynaptic glutamate regulates postsynaptic ionotropic glutamate
receptor number during synaptogenesis. To test this idea, we genetically manipulated …