Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is changing…

1The past decade has witnessed a burst of speculation and data about how astrocyte dysfunction
contributes to the phenotypes of the well known neurodegenerative diseases such as …

Alexander disease is a rare disorder of the central nervous system of unknown etiology 1, 2.
Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, …

Mice lacking the voltage-gated potassium channel α subunit, K V 1.1, display frequent
spontaneous seizures throughout adult life. In hippocampal slices from homozygous K V 1.1 null …

Fukuyama congenital muscular dystrophy (FCMD), muscle–eye–brain disease (MEB), and
Walker–Warburg syndrome are congenital muscular dystrophies (CMDs) with associated …

A high percentage of transgenic mice developing from eggs microinjected with plasmids
containing the SV40 early region genes and a metallothionein fusion gene develop tumors …

Activation of the transcription factor Nrf2 in astrocytes coordinates the upregulation of antioxidant
defenses and confers protection to neighboring neurons. Dominant mutations in Cu/Zn-…

Glial fibrillary acidic protein (GFAP) is a member of the family of intermediate filament
structural proteins and is found predominantly in astrocytes of the central nervous system (CNS). …

With the goal of performing astrocyte‐specific modification of genes in the mouse, we have
generated a transgenic line expressing Cre recombinase under the control of the human glial …