User profiles for A. J. Eisch

Amelia Eisch

Univ Pennsylvania Perelman School of Medicine/Children's Hospital of Philadelphia (CHOP …
Verified email at chop.edu
Cited by 28339

[HTML][HTML] Neurobiology of depression

EJ Nestler, M Barrot, RJ DiLeone, AJ Eisch, SJ Gold… - Neuron, 2002 - cell.com
Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Depression and hippocampal neurogenesis: a road to remission?

AJ Eisch, D Petrik - Science, 2012 - science.org
Adult-generated hippocampal neurons are required for mood control and antidepressant
efficacy, raising hopes that someday we can harness the power of new neurons to treat mood …

Not (ch) just development: Notch signalling in the adult brain

JL Ables, JJ Breunig, AJ Eisch, P Rakic - Nature Reviews …, 2011 - nature.com
The Notch pathway is often regarded as a developmental pathway, but components of
Notch signalling are expressed and active in the adult brain. With the advent of more …

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

JE Malberg, AJ Eisch, EJ Nestler… - Journal of …, 2000 - Soc Neuroscience
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may
contribute to the pathophysiology of depression. The aim of this study was to investigate the …

[HTML][HTML] Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions

…, RL Neve, S Chakravarty, A Kumar, AJ Eisch… - Cell, 2007 - cell.com
While stressful life events are an important cause of psychopathology, most individuals
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …

Opiates inhibit neurogenesis in the adult rat hippocampus

AJ Eisch, M Barrot, CA Schad… - Proceedings of the …, 2000 - National Acad Sciences
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat
hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal …

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

…, F Hollis, H Wang, MA Noonan, Y Ren, AJ Eisch… - Nature …, 2010 - nature.com
… We also thank AJ Robison for helpful discussions and comments on the manuscript. This
work was supported by grants from the National Institute on Drug Abuse and National Institute …

CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli

…, RJ DiLeone, O Berton, AJ Eisch… - Proceedings of the …, 2002 - National Acad Sciences
The transcription factor cAMP response element (CRE)-binding protein (CREB) has been
shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, …

Dynamic contribution of nestin-expressing stem cells to adult neurogenesis

…, CA Greer, CD Mandyam, AJ Eisch - Journal of …, 2007 - Soc Neuroscience
Understanding the fate of adult-generated neurons and the mechanisms that influence them
requires consistent labeling and tracking of large numbers of stem cells. We generated a …

Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression

AJ Eisch, CA Bolańos, J De Wit, RD Simonak… - Biological …, 2003 - Elsevier
BACKGROUND: Previous work has shown that brain-derived neurotrophic factor (BDNF) and
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …