User profiles for A. J. Eisch
Amelia EischUniv Pennsylvania Perelman School of Medicine/Children's Hospital of Philadelphia (CHOP … Verified email at chop.edu Cited by 28339 |
[HTML][HTML] Neurobiology of depression
Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …
understanding the neurobiology of depression is slow. Several promising hypotheses of …
Depression and hippocampal neurogenesis: a road to remission?
Adult-generated hippocampal neurons are required for mood control and antidepressant
efficacy, raising hopes that someday we can harness the power of new neurons to treat mood …
efficacy, raising hopes that someday we can harness the power of new neurons to treat mood …
Not (ch) just development: Notch signalling in the adult brain
The Notch pathway is often regarded as a developmental pathway, but components of
Notch signalling are expressed and active in the adult brain. With the advent of more …
Notch signalling are expressed and active in the adult brain. With the advent of more …
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may
contribute to the pathophysiology of depression. The aim of this study was to investigate the …
contribute to the pathophysiology of depression. The aim of this study was to investigate the …
[HTML][HTML] Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
While stressful life events are an important cause of psychopathology, most individuals
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …
Opiates inhibit neurogenesis in the adult rat hippocampus
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat
hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal …
hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal …
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
… We also thank AJ Robison for helpful discussions and comments on the manuscript. This
work was supported by grants from the National Institute on Drug Abuse and National Institute …
work was supported by grants from the National Institute on Drug Abuse and National Institute …
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
The transcription factor cAMP response element (CRE)-binding protein (CREB) has been
shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, …
shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, …
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
…, CA Greer, CD Mandyam, AJ Eisch - Journal of …, 2007 - Soc Neuroscience
Understanding the fate of adult-generated neurons and the mechanisms that influence them
requires consistent labeling and tracking of large numbers of stem cells. We generated a …
requires consistent labeling and tracking of large numbers of stem cells. We generated a …
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
BACKGROUND: Previous work has shown that brain-derived neurotrophic factor (BDNF) and
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …