Macromolecular synthesis contributes to nociceptive response to subcutaneous formalin injection in mice

Neuropharmacology. 1998 Aug;37(8):1091-3. doi: 10.1016/s0028-3908(98)00099-9.

Abstract

Subcutaneous formalin injection into the hindpaw produces two phases of nociceptive response: phase 1 and phase 2. Activation of N-methyl-D-aspartate (NMDA) receptors in the spinal cord during phase 1 is important for phase 2. We report here that phase 2 but not phase 1 requires new RNA and protein synthesis in the spinal cord.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Dactinomycin / pharmacology
  • Injections, Spinal
  • Injections, Subcutaneous
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nucleic Acid Synthesis Inhibitors / pharmacology
  • Pain / physiopathology*
  • Pain Measurement
  • Protein Biosynthesis*
  • Protein Synthesis Inhibitors / pharmacology
  • RNA / biosynthesis*
  • Reflex / drug effects

Substances

  • Nucleic Acid Synthesis Inhibitors
  • Protein Synthesis Inhibitors
  • Dactinomycin
  • RNA