Abstract
Subcutaneous formalin injection into the hindpaw produces two phases of nociceptive response: phase 1 and phase 2. Activation of N-methyl-D-aspartate (NMDA) receptors in the spinal cord during phase 1 is important for phase 2. We report here that phase 2 but not phase 1 requires new RNA and protein synthesis in the spinal cord.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analysis of Variance
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Animals
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Dactinomycin / pharmacology
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Injections, Spinal
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Injections, Subcutaneous
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Male
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Mice
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Mice, Inbred BALB C
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Nucleic Acid Synthesis Inhibitors / pharmacology
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Pain / physiopathology*
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Pain Measurement
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Protein Biosynthesis*
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Protein Synthesis Inhibitors / pharmacology
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RNA / biosynthesis*
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Reflex / drug effects
Substances
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Nucleic Acid Synthesis Inhibitors
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Protein Synthesis Inhibitors
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Dactinomycin
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RNA