Abstract
This review summarizes our current knowledge of the regulation of the cell cycle by the cyclin-dependent kinase family (CDK). The CDKs are regulated both by binding their cyclin partners, and by phosphorylation of certain key residues. Cyclin synthesis and destruction are regulated during the cell cycle, and there are two broad classes of cyclins: the START or G1 cyclins, and the mitotic or G2 cyclins. In vivo the different cyclins and CDKs demonstrate a high degree of specificity in binding to each other, and it appears that specific cyclin-CDK complexes are involved in the regulation of particular cell cycle events.
MeSH terms
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Amino Acid Sequence
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Animals
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CDC2 Protein Kinase / physiology*
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CDC2-CDC28 Kinases*
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Cell Cycle
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Cyclin-Dependent Kinase 2
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinase 6
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Cyclin-Dependent Kinases / physiology*
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Cyclins / metabolism
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Humans
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Molecular Sequence Data
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Phosphorylation
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins*
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Retinoblastoma Protein / metabolism
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Signal Transduction
Substances
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Cyclins
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Proto-Oncogene Proteins
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Retinoblastoma Protein
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Protein Serine-Threonine Kinases
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CDC2 Protein Kinase
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CDC2-CDC28 Kinases
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CDK2 protein, human
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CDK4 protein, human
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CDK6 protein, human
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Cyclin-Dependent Kinase 2
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinase 6
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Cyclin-Dependent Kinases