Abstract
In cynomolgus monkeys, midbrain neurons immunoreactive (IR) for the calcium-binding protein calbindin D-28k (CaBP) occur principally in the dorsal tier of substantia nigra pars compacta (SNc) and in the ventral tegmental area (VTA), and most of these neurons co-express tyrosine hydroxylase (TH). In monkeys rendered parkinsonian (PD) after MPTP injections, CaBP-IR neurons are much less severely affected than TH-IR neurons in SNc and in VTA, and most spared neurons in SNc/VTA display both CaBP and TH immunoreactivity. These results reveal that, in contrast to the situation in other neurodegenerative diseases, CaBP may be used as a marker for a specific neuronal population that is less prone to degeneration in Parkinson's disease.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Animals
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Calbindins
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Dopamine / metabolism*
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Immunohistochemistry
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Macaca fascicularis
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Mesencephalon / cytology
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Mesencephalon / metabolism*
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Mesencephalon / pathology
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Neurons / cytology
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Neurons / metabolism*
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Neurons / pathology
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Organ Specificity
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / metabolism*
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Parkinson Disease, Secondary / pathology
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Reference Values
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S100 Calcium Binding Protein G / analysis
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S100 Calcium Binding Protein G / metabolism*
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Tyrosine 3-Monooxygenase / analysis
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Tyrosine 3-Monooxygenase / metabolism*
Substances
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Calbindins
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S100 Calcium Binding Protein G
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Tyrosine 3-Monooxygenase
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Dopamine