Abstract
This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Calbindins
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Epilepsy / physiopathology*
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Hippocampus / pathology
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Hippocampus / physiopathology*
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Hippocampus / ultrastructure
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Humans
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Interneurons / pathology
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Interneurons / ultrastructure
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Nerve Net / physiopathology*
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Neural Inhibition / physiology*
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Neuronal Plasticity / physiology*
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Parvalbumins / metabolism
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Recovery of Function / physiology*
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S100 Calcium Binding Protein G / metabolism
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gamma-Aminobutyric Acid / metabolism
Substances
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Calbindins
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Parvalbumins
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S100 Calcium Binding Protein G
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gamma-Aminobutyric Acid