Abstract
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor / methods
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Microtubules / drug effects*
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Purines / chemistry
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Purines / pharmacology
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Structure-Activity Relationship
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Triazines / chemical synthesis*
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Triazines / chemistry
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Triazines / pharmacology*
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Zebrafish / embryology*
Substances
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Antineoplastic Agents
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Purines
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Triazines
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myoseverin