Abstract
The year 2006 marks the 100th anniversary of the first Nobel Prize for Physiology or Medicine for studies in the field of the Neurosciences jointly awarded to Camillo Golgi and Santiago Ramón y Cajal for their key contributions to the study of the nervous system. This award represented the beginning of the modern era of neuroscience. Using the Golgi method, Cajal made fundamental, but often unappreciated, contributions to the study of the relationship between brain plasticity and mental processes. Here, I focus on some of these early experiments and how they continue to influence studies of brain plasticity.
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References
DeFelipe, J. Sesquicentennial of the birthday of Santiago Ramón y Cajal (1852–2002), the father of modern neuroscience. Trends Neurosci. 25, 481–484 (2002).
Ramón y Cajal, S. Estudios Sobre la Degeneración y Regeneración del Sistema Nervioso (Moya, Madrid, 1913–1914); reprinted and edited with additional translations by DeFelipe, J. & Jones, E. G. Cajal's Degeneration and Regeneration of the Nervous System (Oxford Univ. Press, New York, 1991).
Sotelo, C. The chemotactic hypothesis of Cajal a century behind. Changing views of Cajal's neuron. Prog. Brain Res. 136, 11–20 (2002).
Shepherd, G. M. Foundations of the Neuron Doctrine (Oxford Univ. Press, New York, 1991).
Stahnisch, F. W. & Nitsch, R. Santiago Ramón y Cajal's concept of neuronal plasticity: the ambiguity lives on. Trends Neurosci. 25, 589–591 (2002).
Stahnisch, F. W. Making the brain plastic: early neuroanatomical staining techniques and the pursuit of structural plasticity. J. Hist. Neurosci. 12, 413–435 (2003).
Jones, E. G. Plasticity and neuroplasticity. J. Hist. Neurosci. 13, 293 (2004).
Jones, E. G. Plasticity and neuroplasticity. J. Hist. Neurosci. 9, 37–39 (2000).
Berlucchi, G. The origin of the term plasticity in the neurosciences: Ernesto Lugaro and chemical synaptic transmission. J. Hist. Neurosci. 11, 305–309 (2002).
Ramón y Cajal, S. Consideraciones generales sobre la morfología de la célula nerviosa. La Veterinaria Española 37, 257–260, 273–275, 289–291 (1894) (in Spanish).
Golgi, C. Sulla struttura della sostanza grigia del cervello (Comunicazione preventiva). Gaz. Med. Ital. Lombardia 33, 244–246 (1873) (in Italian).
Ramón y Cajal, S. Estructura de los centros nerviosos de las aves. Rev. Trim. Histol. Norm. Patol. 1, 1–10 (1888) (in Spanish).
Wiedersheim, R. Bewegungserscheinungen im gehirn von leptodora hyalina. Anat. Anz. 5, 673–679 (1890) (in German).
Rabl-Rückhard, H. Sind die ganglienzellen amöboid? Eine hypothese zur mechanik psychischer vorgänge. Neurol. Centralbl. 9, 199–200 (1890) (in German).
Lépine, R. Sur un cas d'hystérie á form particulière. Rev. Méd. 14, 713–728 (1894) (in French).
Duval, M. Hypothèses sur la physiologie des centres nerveux; théorie histologique du sommeil. Compt. Rend. Soc. Biol. 47, 74–77 (1895) (in French).
Ramón y Cajal, S. Algunas conjeturas sobre el mecanismo anatómico de la ideación, asociación y atención. Rev. Med. Cirug. Prác. 36, 497–508 (1895) (in Spanish).
Garcia-Segura, L. M., Chowen, J. A., Parducz, A. & Naftolin, F. Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms. Prog. Neurobiol. 44, 279–307 (1994).
Theodosis D. T. & Poulain, D. A Contribution of astrocytes to activity-dependent structural plasticity in the adult brain. Adv. Exp. Med. Biol. 468, 175–182 (1999).
Ramón y Cajal, S. El nuevo concepto de la histología de los centros nerviosos. Rev. Ciencias Méd. Barcelona 18, 361–376, 457–476, 505–520, 529–541 (1892) (in Spanish).
Tanzi, E. I fatti e le induzione nell'odierna istologia del sistema nervoso. Riv. Sper. Freniat. Med. Leg. 19, 419–472 (1893) (in Italian).
Ramón y Cajal, S. The Croonian lecture: la fine structure des centres nerveux. Proc. Royal Soc. Lond. 55, 444–468 (1894) (in French).
Jones, E. G. Santiago Ramón y Cajal and the Croonian lecture, March 1894. Trends Neurosci. 17, 190–192 (1994).
Ramón y Cajal, S. Consideraciones Generales Sobre la Morfología de la Célula Nerviosa (Moya, Madrid, 1894) (in Spanish).
Volkmar, F. R. & Greenough, W. T. Rearing complexity affects branching of dendrites in the visual cortex of the rat. Science 176, 1145–1147 (1972).
Globus, A., Rosenzweig, M. R., Bennett, E. L. & Diamond, M. C. Effects of differential experience on dendritic spine counts in rat cerebral cortex. J. Comp. Physiol. Psychol. 82, 175–181 (1973).
Benavides-Piccione, R. et al. On dendrites in Down syndrome and DS murine models: a spiny way to learn. Progr. Neurobiol. 74, 111–126 (2004).
Ramón y Cajal, S. Textura de las circunvoluciones cerebrales de los mamíferos inferiores. Nota preventiva. Gac. Méd. Catalana 1, 22–31 (1890) (in Spanish).
DeFelipe, J. & Jones, E. G. Cajal on the Cerebral Cortex (Oxford University Press, New York, 1988).
Ramón y Cajal, S. ¿Neuronismo o reticularismo? Las pruebas objetivas de la unidad anatómica de las células nerviosas. Arch. Neurobiol. 13, 217–291, 579–646 (1933) (in Spanish).
Portera-Cailliau, C. & Yuste, R. On the function of dendritic filopodia. Rev. Neurol. 33, 1158–1166 (2001).
Gray, E. G. Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 183, 1592–1593 (1959).
DeFelipe, J. & Fariñas, I. The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Prog. Neurobiol. 39, 563–607 (1992).
Globus, A. & Scheibel, A. The effect of visual deprivation on cortical neurons: a Golgi study. Exp. Neurol. 19, 331–345 (1967).
Valverde, F. Rate and extent of recovery from dark rearing in the visual cortex of the mouse. Brain Res. 33, 1–11 (1971).
Marín-Padilla, M. Structural abnormalities of the cerebral cortex in human chromosomal aberrations. A Golgi study. Brain Res. 44, 625–629 (1972).
Purpura, D. Dendritic spine 'dysgenesis' and mental retardation. Science 186, 1126–1128 (1974).
Yuste, R. & Bonhoeffer, T. Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nature Rev. Neurosci. 5, 24–34 (2004).
Segal, M. Dendritic spines and long-term plasticity. Nature Rev. Neurosci. 6, 277–284 (2005).
Hayashi, Y. & Majewska, A. K. Dendritic spine geometry: functional implication and regulation. Neuron 19, 529–532 (2005).
Matus, A. Growth of dendritic spines: a continuing story. Curr. Opin. Neurobiol. 15, 67–72 (2005).
Demoor, J. La plasticité morphologique des neurones cérébraux. Arch. Biol. Bruxelles 14, 723–752 (1896) (in French).
Stefanowska, M. Les appendices terminaux des dendrites cérébraux et leur différents états physiologiques. Ann. Soc. R. Sci. Méd. Nat. Brux. 6, 351–407 (1897) (in French).
Ramón y Cajal, S. Textura del Sistema Nervioso del Hombre y de los Vertebrados (Moya, Madrid, 1899, 1904) (in Spanish).
Black, S. E. Pseudopods and synapses: the amoeboid theories of neuronal mobility and the early formulation of the synapse concept, 1894–1900. Bull. Hist. Med. 55, 34–58 (1981).
Blomberg, F., Cohen, R. & Siekevitz, P. The structure of postsynaptic densities isolated from dog cerebral cortex. II. Characterization and arrangement of some of the major proteins within the structure. J. Cell Biol. 86, 831–845 (1977).
Crick, F. Do spines twitch? Trends Neurosci. 5, 44–46 (1982).
Fifková, E. & Delay, R. J. Cytoplasmic actin in neuronal processes as a possible mediator of synaptic plasticity. J. Cell Biol. 95, 345–350 (1982).
Matus, A., Ackermann, M., Pehling, G., Byers, H. R. & Fujiwara, K. High actin concentrations in brain dendritic spines and postsynaptic densities. Proc. Natl Acad. Sci. USA 79, 7590–7594 (1982).
Fischer, M., Kaech, S., Knutti, D. & Matus, A. Rapid actin-based plasticity in dendritic spines. Neuron 20, 847–854 (1998).
Denk, W. et al. Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy. J. Neurosci. Meth. 54, 151–162 (1994).
Scout, E. K. & Luo, L. How do dendrites take their shape? Nature Neurosci. 4, 359–365 (2001).
Nimchinsky, E., Sabatini, B. L. & Svoboda, K. Structure and function of dendritic spines. Annu. Rev. Physiol. 64, 313–353 (2002).
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C. A. & Yuste, R. Developmental regulation of spine motility in mammalian CNS. Proc. Natl Acad. Sci. USA 96, 13438–13443 (1999).
Portera-Cailliau, C., Pan, D. T. & Yuste, R. Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia. J. Neurosci. 23, 7129–7142 (2003).
Lendvai, B., Stern, E., Chen, B. & Svoboda, K. Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo. Nature 404, 876–881 (2000).
Trachtenberg, J. T. et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420, 788–794 (2002).
Grutzendler, J., Kasthuri, N. & Gan, W. B. Long-term dendritic spine stability in the adult cortex. Nature 420, 812–816 (2002).
Tello, F. La influencia del neurotropismo en la regeneración de los centros nerviosos. Trab. Lab. Invest. Biol. Univ. Madr. 9, 123–159 (1911) (in Spanish).
Jones, E. G. The neuron doctrine. J. Hist. Neurosci. 3, 3–20 (1994).
von Waldeyer-Hartz, W. Über einige neuere forschungen im gebiete der anatomie des centralnervensystems. Dtsch. Med. Wschr. 17, 1213–1218, 1244–1246, 1267–1269, 1287–1289, 1331–1332, 1352–1356 (1891) (in German).
Portera-Cailliau, C. & Yuste, R. Espinas y filopodios en el cerebro. Mente y Cerebro 9, 10–21 (2004) (in Spanish).
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The author is grateful to E. G. Jones and R. Yuste for their helpful comments on the manuscript.
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DeFelipe, J. Brain plasticity and mental processes: Cajal again. Nat Rev Neurosci 7, 811–817 (2006). https://doi.org/10.1038/nrn2005
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DOI: https://doi.org/10.1038/nrn2005
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