Abstract
In the cerebral cortex of the developing murine central nervous system, formation of neurons and astrocytes can be modulated by transcription factors with basic helix-loop-helix (bHLH) domains. However, transcription factors that promote formation of oligodendrocytes have yet to be identified. We show here that ectopic expression of the bHLH gene Olig1 promotes oligodendrocyte formation while suppressing neuronal survival in the cerebral cortex of developing mice.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cai, L., Morrow, E. M. & Cepko, C. L. Development 127, 3021–3030 (2000).
Levison, S. W. & Goldman, J. E. Neuron 10, 201–212 (1993).
Fisher, F. & Goding, C. R. EMBO J. 11, 4103–4109 (1992).
Kondo, T. & Raff, M. EMBO J. 19, 1998–2007 (2000).
Wang, S., Sdrulla, A. D., Johnson, J. E., Yokota, Y. & Barres, B. A. Neuron 29, 603–614 (2001).
Kondo, T. & Raff, M. Development 127, 2989–2998 (2000).
Barres, B. in Molecular and Cellular Approaches to Neural Development (eds. Cowan, W. M., Jessell, T. M. & Zipursky, S. L.) 64–107 (New York, 1997).
Calver, A. R. et al. Neuron 20, 869–882 (1998).
Furukawa, T., Mukherjee, S., Bao, Z. Z., Morrow, E. M. & Cepko, C. L. Neuron 26, 383–394 (2000).
Hojo, M. et al. Development 127, 2515–2522 (2000).
Lu, Q. R. et al. Neuron 25, 317–329 (2000).
Zhou, Q., Wang, S. & Anderson, D. J. Neuron 25, 331–343 (2000).
Holtzman, D. M. et al. Proc. Natl. Acad. Sci. USA 93, 13333–13338 (1996).
Korenberg, J. R. Prog. Clin. Biol. Res. 373, 43–52 (1991).
Hattori, M. et al. Nature 405, 311–319 (2000).
Acknowledgements
This research was funded by grants from Charles Dana foundation, National Institutes of Child Health and Neurological Disease and Stroke (C.D.S., D.R.) and Howard Hughes Medical Institute (C.L.C.). Q.R.L. received an NRSA postdoctoral fellowship award from NIH. We thank P. Dahia and J. Alberta for discussions.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Lu, Q., Cai, L., Rowitch, D. et al. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci 4, 973–974 (2001). https://doi.org/10.1038/nn718
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn718
This article is cited by
-
RETRACTED ARTICLE: Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice
BMC Complementary Medicine and Therapies (2017)
-
Polarized Macrophages Have Distinct Roles in the Differentiation and Migration of Embryonic Spinal-cord-derived Neural Stem Cells After Grafting to Injured Sites of Spinal Cord
Molecular Therapy (2015)
-
Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus
Molecular Psychiatry (2014)
-
Emerging Roles of Peroxisome Proliferator-Activated Receptors (PPARs) in the Regulation of Neural Stem Cells Proliferation and Differentiation
Stem Cell Reviews (2008)
-
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Nature Reviews Neuroscience (2006)