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Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity

Nature Neuroscience volume 8, pages 839–841 (2005)Cite this article

Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo.

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References

  1. Sjostrom, P.J. & Nelson, S.B. Curr. Opin. Neurobiol. 12, 305–314 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Paulsen, O. & Sejnowski, T.J. Curr. Opin. Neurobiol. 10, 172–179 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Goldberg, J., Holthoff, K. & Yuste, R. Trends Neurosci. 25, 433–435 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Stuart, G., Spruston, N., Sakmann, B. & Hausser, M. Trends Neurosci. 20, 125–131 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. Waters, J., Schaefer, A. & Sakmann, B. Prog. Biophys. Mol. Biol. 87, 145–170 (2005).

    Article  PubMed  Google Scholar 

  6. Markram, H., Lubke, J., Frotscher, M. & Sakmann, B. Science 275, 213–215 (1997).

    Article  CAS  PubMed  Google Scholar 

  7. Feldman, D.E. Neuron 27, 45–56 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Sjostrom, P.J., Turrigiano, G.G. & Nelson, S.B. Neuron 32, 1149–1164 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Debanne, D., Gahwiler, B.H. & Thompson, S.M. J. Physiol. (Lond.) 507, 237–247 (1998).

    Article  CAS  Google Scholar 

  10. Bi, G.Q. & Poo, M.M. J. Neurosci. 18, 10464–10472 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Froemke, R.C. & Dan, Y. Nature 416, 433–438 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. Wang, H.X., Gerkin, R.C., Nauen, D.W. & Bi, G.Q. Nat. Neurosci. 8, 187–193 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Spruston, N., Schiller, Y., Stuart, G. & Sakmann, B. Science 268, 297–300 (1995).

    Article  CAS  PubMed  Google Scholar 

  14. Callaway, J.C. & Ross, W.N. J. Neurophysiol. 74, 1395–1403 (1995).

    Article  CAS  PubMed  Google Scholar 

  15. Golding, N.L., Kath, W.L. & Spruston, N. J. Neurophysiol. 86, 2998–3010 (2001).

    Article  CAS  PubMed  Google Scholar 

  16. Stuart, G., Schiller, J. & Sakmann, B. J. Physiol. (Lond.) 505, 617–632 (1997).

    Article  CAS  Google Scholar 

  17. Nevian, T. & Sakmann, B. J. Neurosci. 24, 1689–1699 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Koester, H.J. & Sakmann, B. Proc. Natl. Acad. Sci. USA 95, 9596–9601 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Spruston, N., Jonas, P. & Sakmann, B. J. Physiol. (Lond.) 482, 325–352 (1995).

    Article  CAS  Google Scholar 

  20. Kampa, B.M., Clements, J., Jonas, P. & Stuart, G.J. J. Physiol. (Lond.) 556, 337–345 (2004).

    Article  CAS  Google Scholar 

  21. Vargas-Caballero, M. & Robinson, H.P. J. Neurophysiol. 89, 2778–2783 (2003).

    Article  CAS  PubMed  Google Scholar 

  22. Vargas-Caballero, M. & Robinson, H.P. J. Neurosci. 24, 6171–6180 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Golding, N.L., Staff, N.P. & Spruston, N. Nature 418, 326–331 (2002).

    Article  CAS  PubMed  Google Scholar 

  24. Kovalchuk, Y., Eilers, J., Lisman, J. & Konnerth, A. J. Neurosci. 20, 1791–1799 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Stuart, G.J. & Hausser, M. Nat. Neurosci. 4, 63–71 (2001).

    Article  CAS  PubMed  Google Scholar 

  26. Magee, J.C. & Johnston, D. Science 275, 209–213 (1997).

    Article  CAS  PubMed  Google Scholar 

  27. Hausser, M., Spruston, N. & Stuart, G.J. Science 290, 739–744 (2000).

    Article  CAS  PubMed  Google Scholar 

  28. Schiller, J., Major, G., Koester, H.J. & Schiller, Y. Nature 404, 285–289 (2000).

    Article  CAS  PubMed  Google Scholar 

  29. Thomas, M.J., Watabe, A.M., Moody, T.D., Makhinson, M. & O'Dell, T.J. J. Neurosci. 18, 7118–7126 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Hoffman, D.A., Sprengel, R. & Sakmann, B. Proc. Natl. Acad. Sci. USA 99, 7740–7745 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Kamondi, A., Acsady, L. & Buzsaki, G. J. Neurosci. 18, 3919–3928 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Polsky, A., Mel, B.W. & Schiller, J. Nat. Neurosci. 7, 621–627 (2004).

    Article  CAS  PubMed  Google Scholar 

  33. Buzsaki, G., Geisler, C., Henze, D.A. & Wang, X.J. Trends Neurosci. 27, 186–193 (2004).

    Article  CAS  PubMed  Google Scholar 

  34. Pouille, F. & Scanziani, M. Science 293, 1159–1163 (2001).

    Article  CAS  PubMed  Google Scholar 

  35. Pouille, F. & Scanziani, M. Nature 429, 717–723 (2004).

    Article  CAS  PubMed  Google Scholar 

  36. Tsubokawa, H. & Ross, W.N. J. Neurophysiol. 76, 2896–2906 (1996).

    Article  CAS  PubMed  Google Scholar 

  37. Williams, S.R. Nat. Neurosci. 7, 961–967 (2004).

    Article  CAS  PubMed  Google Scholar 

  38. Froemke, R.C., Poo, M.M. & Dan, Y. Nature 434, 221–225 (2005).

    Article  CAS  PubMed  Google Scholar 

  39. Dudek, S.M. & Bear, M.F. Proc. Natl. Acad. Sci. USA 89, 4363–4367 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Staubli, U.V. & Ji, Z.X. Brain Res. 714, 169–176 (1996).

    Article  CAS  PubMed  Google Scholar 

  41. Sjostrom, P.J., Turrigiano, G.G. & Nelson, S.B. J. Neurophysiol. 92, 3338–3343 (2004).

    Article  CAS  PubMed  Google Scholar 

  42. Holthoff, K., Kovalchuk, Y., Yuste, R. & Konnerth, A. J. Physiol. (Lond.) 560, 27–36 (2004).

    Article  CAS  Google Scholar 

  43. Abbott, L.F. & Nelson, S.B. Nat. Neurosci. 3 suppl. Suppl, 1178–1183 (2000).

    Article  CAS  PubMed  Google Scholar 

  44. Pike, F.G., Meredith, R.M., Olding, A.W. & Paulsen, O. J. Physiol. (Lond.) 518, 571–576 (1999).

    Article  CAS  Google Scholar 

  45. Artola, A., Brocher, S. & Singer, W. Nature 347, 69–72 (1990).

    Article  CAS  PubMed  Google Scholar 

  46. Dudek, S.M. & Bear, M.F. J. Neurosci. 13, 2910–2918 (1993).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Huerta, P.T. & Lisman, J.E. Neuron 15, 1053–1063 (1995).

    Article  CAS  PubMed  Google Scholar 

  48. Holscher, C., Anwyl, R. & Rowan, M.J. J. Neurosci. 17, 6470–6477 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Hyman, J.M., Wyble, B.P., Goyal, V., Rossi, C.A. & Hasselmo, M.E. J. Neurosci. 23, 11725–11731 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Wespatat, V., Tennigkeit, F. & Singer, W. J. Neurosci. 24, 9067–9075 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Fusi, S., Drew, P.J. & Abbott, L.F. Neuron 45, 599–611 (2005).

    Article  CAS  PubMed  Google Scholar 

  52. Malenka, R.C. Neuron 6, 53–60 (1991).

    Article  CAS  PubMed  Google Scholar 

  53. Lisman, J., Schulman, H. & Cline, H. Nat. Rev. Neurosci. 3, 175–190 (2002).

    Article  CAS  PubMed  Google Scholar 

  54. Lisman, J.E. & Zhabotinsky, A.M. Neuron 31, 191–201 (2001).

    Article  CAS  PubMed  Google Scholar 

  55. Bradshaw, J.M., Kubota, Y., Meyer, T. & Schulman, H. Proc. Natl. Acad. Sci. USA 100, 10512–10517 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Frey, U., Schroeder, H. & Matthies, H. Brain Res. 522, 69–75 (1990).

    Article  CAS  PubMed  Google Scholar 

  57. Lisman, J.E. & Grace, A.A. Neuron 46, 703–713 (2005).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Biology Department, Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA

    John Lisman

  2. Department of Neurobiology & Physiology, Institute for Neuroscience, Northwestern University, 2205 Tech Dr., Evanston, 60208, Illinois, USA

    Nelson Spruston

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  2. Nelson Spruston
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Lisman, J., Spruston, N. Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity. Nat Neurosci 8, 839–841 (2005). https://doi.org/10.1038/nn0705-839

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