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Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

Abstract

The mitogens which modulate cell–cell interactions during development of the central nervous system are unknown. One of the few interactions sufficiently well understood to allow identification of such molecules involves the two glial lineages which make up the rat optic nerve. One population of glial cells in this tissue, the type-1 astrocytes1, secrete a soluble factor(s) which promotes division of a second population of bipotential oligoden-drocyte/type-2 astrocyte (O-2A) progenitor cells2; these progenitors give rise to oligodendrocytes, which myelinate large axons in the CNS, and type-2 astrocytes, which enwrap bare axons at nodes of Ranvier3,4. Type-1 astrocytes also promote progenitor motility5, and inhibit the premature differentiation of progenitors into oligodendrocytes which occur when these cells are grown in the absence of type-1 astrocytes2,3. We have now found that platelet-derived growth factor mimics the effects of type-1 astrocytes on O-2A progenitor cells, and antibodies to PDGF block the effects of type-1 astrocytes.

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References

  1. Raff, M. C., Abney, E. R., Cohen, J., Lindsay, R. & Noble, M. J. Neurosci. 3, 1289–1300 (1983).

    Article  CAS  Google Scholar 

  2. Noble, M. & Murray, K. EMBO J. 3, 2243–2247 (1984).

    Article  CAS  Google Scholar 

  3. Raff, M. C., Miller, R. H. & Noble, M. Nature 303, 390–396 (1983).

    Article  ADS  CAS  Google Scholar 

  4. Ffrench-Constant, C. & Raff, M. C. Nature 323, 335–338 (1986).

    Article  ADS  CAS  Google Scholar 

  5. Small, R. K., Riddle, P. & Noble, M. Nature 328, 155–157 (1987).

    Article  ADS  CAS  Google Scholar 

  6. Raff, M. C., Abney, E. R. & Fok-Seang, J. Cell 42, 61–69 (1985).

    Article  CAS  Google Scholar 

  7. Raff, M. C., Lillien, L. E., Richardson, W. D., Burne, J. F. & Noble, M. D. Nature 333, 562–565.

  8. Temple, S. & Raff, M. C. Cell 44, 773–779 (1986).

    Article  CAS  Google Scholar 

  9. Mirsky, R. et al. J. Cell Biol. 84, 483–494 (1980).

    Article  CAS  Google Scholar 

  10. Hughes, S. & Raff, M. C. Development 101, 157–167 (1987).

    CAS  PubMed  Google Scholar 

  11. Ross, R., Raines, E. W. & Bowen-Pope, D. F. Cell 46, 155–169 (1986).

    Article  CAS  Google Scholar 

  12. Stroobant, P. & Waterfield, M. D. EMBO J. 3, 2963–2967 (1984).

    Article  CAS  Google Scholar 

  13. Eisenbarth, G. S., Walsh, F. S. & Nirenberg, M. Proc. natn Acad. Sci. U.S.A. 76, 4913–4917 (1979).

    Article  ADS  CAS  Google Scholar 

  14. Ranscht, B., Clapshaw, P. A., Price, J., Noble, M. & Seifert Proc. Natn. Acad. Sci. U.S.A. 79, 2709–2713 (1982).

    Article  ADS  CAS  Google Scholar 

  15. Bignami, A., Eng, L. F., Dahi, D. & Uyeda, C. T. Brain Res. 43, 429–435 (1972).

    Article  CAS  Google Scholar 

  16. Pruss, R. M. Nature 280, 688–690 (1979).

    Article  ADS  CAS  Google Scholar 

  17. Richardson, W. D., Pringle, N., Mosley, M. J., Westermark, B. & Dubois-Dalcq, M. Cell 53, 309–319 (1988).

    Article  CAS  Google Scholar 

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Noble, M., Murray, K., Stroobant, P. et al. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil. Nature 333, 560–562 (1988). https://doi.org/10.1038/333560a0

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