CommentaryA default mode of brain function: A brief history of an evolving idea
Section snippets
The history of a problem
By the early 1980s PET began to receive serious attention as a potential functional neuroimaging device in human subjects. (For a detailed historical account see Raichle, 2000). The study of human cognition with neuroimaging was aided greatly by the involvement of cognitive psychologists in the 1980s whose experimental strategies for dissecting human behaviors fit well with the emerging capabilities of functional brain imaging (Posner and Raichle, 1994). Subtracting functional images acquired
Intrinsic brain activity
Having arrived at the view that the brain has a default mode of function through our analysis of activity decreases, we began to take seriously claims that there was likely much more to brain function than that revealed by experiments manipulating momentary demands of the environment. Two bodies of information have been especially persuasive.
First is the cost of intrinsic activity, which far exceeds that of evoked activity (for a review of this literature see Raichle and Mintun, 2006). It
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