EditorialTonic for what ails us? high-affinity GABAA receptors and alcohol
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Cited by (63)
Pharmacology of Alcohol Use
2022, Comprehensive PharmacologyAlcohol: Neurobiology of Addiction
2021, Alcohol: Neurobiology of AddictionGABA<inf>A</inf> receptor: Positive and negative allosteric modulators
2018, NeuropharmacologySynaptic targets: Chronic alcohol actions
2017, NeuropharmacologyTitrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol
2017, Trends in Pharmacological SciencesCitation Excerpt :Receptors containing the δ subunit, α4β3δ and α6β3δ, are more sensitive to alcohol than are γ-containing GABAA receptors [50]. However, some controversy exists over the alcohol-sensitivity of δ subunit-containing GABAA receptors and the direct action of alcohol at extrasynaptic sites [51,52]. Similarly to other ligand-gated receptors, the alcohol sensitivity of GABAA receptors is subject to modulation by intracellular signaling molecules.
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