Cell
Volume 86, Issue 1, 12 July 1996, Pages 35-46
Journal home page for Cell

Article
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

https://doi.org/10.1016/S0092-8674(00)80075-6Get rights and content
Under an Elsevier user license
open archive

Abstract

Eph family receptor tyrosine kinases have been proposed to control axon guidance and fasciculation. To address the biological functions of the Eph family member Nuk, two mutations in the mouse germline have been generated: a protein null allele (Nuk1) and an allele that encodes a Nuk-βgal fusion receptor lacking the tyrosine kinase and C-terminal domains (NuklacZ). In Nuk1 homozygous brains, the majority of axons forming the posterior tract of the anterior commissure migrate aberrantly to the floor of the brain, resulting in a failure of cortical neurons to link the two temporal lobes. These results indicate that Nuk, a receptor that binds transmembrane ligands, plays a critical and unique role in the pathfinding of specific axons in the mammalian central nervous system.

Cited by (0)