ArticlesPimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity
Section snippets
Experiment 1: does pimozide modify the palatability of a sucrose solution?
In experiment 1, the ability of pimozide to modify sucrose palatability in a 10-min test across 3 trials was assessed in both laboratories, once in a between-subjects design [a replication of a design by Leeb et al. [37]] and once in a within-subjects design (in which each rat serves as its own control, being tested both in drug and vehicle conditions). The tapes from the four experiments were shared and scored by both laboratories. Because the analyses performed by both laboratories were
Experiment 2: does pimozide modify the emission of aversive reactions to quinine?
At first sight, this question would seem to have been answered by the finding of Parker and Lopez [43]that pimozide administration increases aversive gapes to oral infusions of highly concentrated quinine. However, Parker and Lopez reported the absolute number of gapes observable, which is complicated by the suppression of locomotion by pimozide demonstrated in experiment 1 (and found by Parker and Lopez). The complication is that suppression of locomotion could conceivably bias the
General discussion
These results directly contradict the hypothesis that dopamine blockade makes tastes seem more unpalatable. Rather, reactions from all categories (aversive, hedonic, and general activity) appear to be reduced similarly by pimozide administration. The most parsimonious interpretation of these results (and those of previous taste reactivity studies) is that pimozide produces a general sensorimotor impairment of the ability to sustain high rates of effortful taste reactivity components (active
Acknowledgements
We thank Suzanne Erb, Hardy Rideout and Sharon Clarke for their assistance in data collection and scoring of the videotapes. We thank Prof. Brenda Wilson Gillespie and Kathy Welch of the University of Michigan Center for Statistical Consultation and Research for running the statistical analysis for experiment 1B. We also thank Prof. Ray Heller, Wilfrid Laurier University, and Prof. Marc Berridge, Case Western Reserve University, for their assessments of the chemical potency of pimozide
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