A distributed-parameter model of the myelinated nerve fiber
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Modeling the excitation of nerve axons under transcutaneous stimulation
2023, Computers in Biology and MedicineSaltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit
2020, CellCitation Excerpt :The emergent DC properties were consistent with the low capacitance produced by ∼15 myelin lamellae, a conductive nanoscale periaxonal space (∼50 Ω cm) and electrical sealing of the paranodes (∼550 Ω cm; Figures 2 and 3). These findings are in agreement with earlier predicted incomplete insulation by the myelin sheath on the basis of experimental recordings (Barrett and Barrett, 1982; Blight and Someya, 1985; Funch and Faber, 1984) and provide a quantitative framework for axoplasmic, periaxonal, and paranodal resistivity, substantially advancing our understanding of the parameters to model submyelin conduction (Arancibia-Carcámo et al., 2017; Blight, 1985; Dimitrov, 2005; Gow and Devaux, 2008; Halter and Clark, 1991; McIntyre et al., 2002; Richardson et al., 2000; Stephanova and Bostock, 1995; Young et al., 2013). The spatial and temporal evolution of the transaxonal potentials beneath myelin is strikingly complex with gradually attenuating waves toward the middle of the internode (Figures 5 and 6).
Modeling conduction delays in the corpus callosum using MRI-measured g-ratio
2019, NeuroImageCitation Excerpt :Due to the myelin sheath, the voltage progression in the internode can be described as passive. The progression of voltage along both segments of the axons have already been modelled and numerically simulated (e.g. Rushton, 1951; Moore et al., 1978; Haltert and Clark, 1991; Basser, 1993). This understanding of the axon signal conduction, together with knowledge on the axon's electrical properties (Debanne et al., 2011; Bakiri et al., 2011) and the ability to measure its geometry, will allow to implement a model that links white matter structure with function in biophysical terms.
Evolution of rapid nerve conduction
2016, Brain ResearchCitation Excerpt :This was confirmed in another study, which found that the optimal internode length (i.e. the length that corresponds to the maximum conduction velocity) depended on the thickness of the myelin sheath, with the optimal length shifting to longer internodes as the thickness increased (and capacitance dropped) (Castelfranco and Hartline, 2015). Another condition that affects the theoretical results is whether the models describe the myelin sheath as distinct from the axolemma, including current flow in the submyelin space as in “double cable” models (Blight, 1985; Halter and Clark, 1991; Hines and Shrager, 1991; McIntyre et al., 2002). Overall these detailed models show a relationship between conduction velocity and internode length similar to that described by Brill et al. (1977), but the predictions of the effect on conduction velocity of a specific change in internode length can differ (Lasiene et al., 2008; Young et al., 2013a; Young et al., 2013b).
Computer Models of Peripheral Nerves
2015, Nerves and Nerve Injuries: Pain, Treatment, Injury, Disease and Future Directions: Vol 2Resting membrane state as an interplay of electrogenic transporters with various pumps
2023, Pflugers Archiv European Journal of Physiology