Trends in Biochemical Sciences
FrontlinesCyclins and cyclin-dependent kinases: take your partners
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2016, GeneCitation Excerpt :Whereas, the activities and specificities of these kinases are determined by their association with various cyclins and inhibitors which are differentially expressed during the cell cycle. Prevailing hypothesis proposes that proper temporal order of cell cycle was regulated by two major checkpoints(Hartwell and Weinert, 1989; Enoch and Nurse, 1991; Pines, 1993). One occurs at the G1/S transition and controls the initiation of DNA replication, and the other occurs at the G2/M transition just prior to mitosis and cell division.