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Cyclins and cyclin-dependent kinases: take your partners

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    Cyclin is a family of proteins that form a complex with cyclin-dependent kinases. They are constantly activated and inactivated to regulate the cell cycle (Pines, 1993). For instance, cyclins phosphorylation is essential for their function and activation during spermiogenesis (Wolgemuth et al., 2013).

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    Whereas, the activities and specificities of these kinases are determined by their association with various cyclins and inhibitors which are differentially expressed during the cell cycle. Prevailing hypothesis proposes that proper temporal order of cell cycle was regulated by two major checkpoints(Hartwell and Weinert, 1989; Enoch and Nurse, 1991; Pines, 1993). One occurs at the G1/S transition and controls the initiation of DNA replication, and the other occurs at the G2/M transition just prior to mitosis and cell division.

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