Elsevier

Alcohol

Volume 4, Issue 1, January–February 1987, Pages 63-68
Alcohol

Article
Differential concentration-response curves for oral ethanol self-administration in C57BL/6J and BALB/cJ mice

https://doi.org/10.1016/0741-8329(87)90062-0Get rights and content

Abstract

In an earlier study ethanol drinking was induced by reducing mice to 80% of their free-feeding weight and feeding them their daily food allotment prior to the experimental session. The mice were given an ascending series of ethanol concentrations (1 to 8%). The inducing condition was subsequently eliminated to determine if the drinking of 8% ethanol would persist in its absence. Eight percent ethanol served as a reinforcer for the C57BL/6J mice but not for the BALB/cJ mice [12]. The purpose of the present study was to examine strain differences in ethanol maintained behavior over a range of concentrations from 1 to 32% (w/v). Ethanol served as a reinforcer for the C57BL/6J mice at concentrations of 4, 8 and 16%. Lever presses and volume of liquid consumed per unit of body weight were inverted U-shaped functions of ethanol concentration. Post-session blood ethanol levels confirmed intake of pharmacologically significant amounts of ethanol. Results with the BALB/cJ mice were very different from those with the C57BL/6J mice. The level of responding did not increase above baseline levels at any of the concentrations tested, and levels of responding decreased below baseline at 32%. Thus, ethanol did not serve as a reinforcer for the BALB/cJ mice at any of the concentrations tested. These results demonstrate that over a range of ethanol concentrations genotype is an important determinant of ethanol reinforced behavior.

References (44)

  • C.L. Randall et al.

    Ethanol-induced mouse strain differences in locomotor activity

    Pharmacol Biochem Behav

    (1975)
  • M.C. Ritz et al.

    Genetic differences in the establishment of ethanol as a reinforcer

    Pharmacol Biochem Behav

    (1986)
  • J.E. Barrett

    Differential drug effects as a function of the controlling consequences

  • J.K. Belknap et al.

    Alcohol consumption and sensory threshold differences between C57BL/6J and DBA/2J mice

    Physiol Psychol

    (1978)
  • M.E. Carroll et al.

    Intravenous self-administration of etonitazene, cocaine and phencyclidine in rats during food deprivation and satiation

    J Pharmacol Exp Ther

    (1981)
  • J.C. Crabbe

    Sensitivity to ethanol in inbred mice: Genotypic correlations among several behavioral responses

    Behav Neurosci

    (1983)
  • J.C. Crabbe et al.

    Tolerance to ethanol hypothermia in inbred mice: Genotypic correlations with behavioral responses

    Alcohol: Clin Exp Res

    (1982)
  • G. Deneau et al.

    Self-administration of psychoactive substances by the monkey

    Psychopharmacologia

    (1969)
  • G.I. Elmer et al.

    Mouse strain differences in operant self-administration of ethanol

    Behav Genet

    (1987)
  • K. Eriksson

    Genetic selection for voluntary alcohol consumption in the albino rat

    Science

    (1968)
  • J.L. Falk et al.

    Schedule induced physical dependence on ethanol

    Pharmacol Rev

    (1975)
  • F.R. George et al.

    Oral narcotic intake as a reinforcer: Genotype × environment interactions

    Behav Genet

    (1984)
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