Elsevier

Neuroscience Letters

Volume 168, Issues 1–2, 28 February 1994, Pages 254-256
Neuroscience Letters

Letter to the editor
Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family

https://doi.org/10.1016/0304-3940(94)90463-4Get rights and content

Abstract

Since the report of a double mutation at codons 670 and 671 of the amyloid precursor protein (APP) gene identified in two Swedish families with clinically diagnosed Alzheimer's disease (AD), a carrier with dementia has died. Neuropathology confirmed the clinical diagnosis of AD. Genealogical investigations have confirmed that the two families are related to common founders. Two-point linkage analysis of the mutation versus the disease in the revised pedigree now gives a lod score of 7.62.

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