Review
The unique origin of rod photoreceptors in the teleost retina

https://doi.org/10.1016/0166-2236(85)90008-6Get rights and content

Abstract

A population of mitotic cells that produce new neurons has recently been discovered in the layer of photoreceptors in retinas of several species of larval and adult fish. These cells generate new rods which are inserted into the photoreceptor mosaic at locations scattered across the entire expanse of the differentiated retina. Subsequently these new rods establish synaptic connections with retinal neurons already present. The continued production of rods in the fish is apparently needed to maintain visual sensitivity during postembryonic growth of the eye.

References (31)

  • S.S. Easter

    Trends Neurosci.

    (1983)
  • R.L. Meyer

    Exp. Neurol.

    (1978)
  • J.W. Hinds et al.

    Dev. Biol.

    (1974)
  • P. Levitt et al.

    Dev. Biol.

    (1983)
  • S.S. Easter et al.

    Vision Res.

    (1977)
  • H. Müller

    Zool. Jahrb.

    (1952)
  • P.R. Johns et al.

    J. Comp. Neurol.

    (1977)
  • J.H. Kock

    J. Comp. Neurol.

    (1982)
  • S.S. Easter et al.

    J. Neurosci.

    (1981)
  • P.R. Johns

    J. Comp. Neurol.

    (1977)
  • P.R. Johns

    J. Neurosci.

    (1982)
  • J.M. Sandy et al.

    J. Mar. Biol. Assoc. UK

    (1980)
  • P.R. Johns et al.

    Nature (London)

    (1981)
  • J.H.S. Blaxter
  • N.A. Locket
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