Drugs of abuse: anatomy, pharmacology and function of reward pathways

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Abstract

Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumed hedonic property and the drugs' neuropharmacological specificity provide a means of studying the neuropharmacology and neuroanatomy of brain reward. Three major brain systems appear to be involved in drug reward—dopamine, opioid and GABA. Evidence suggests a midbrain-forebrain-extrapyramidal circuit with its focus in the nucleus accumbens. Data implicating dopamine and opioid systems in indirect sympathomimetic and opiate reward include critical elements in both the nucleus accumbens and ventral tegmental areas. Ethanol reward appears to depend on an interaction with the GABAA receptor complex but may also involve common elements such as dopamine and opioid peptides in this midbrain-forebrain-extrapyramidal circuit. These results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.

References (86)

  • G.J. Mogenson et al.

    Prog. Neurobiol.

    (1980)
  • T.W. Robbins et al.

    Int. Rev. Neurobiol.

    (1982)
  • D.C.S. Roberts et al.

    Pharmacol. Biochem. Behav.

    (1980)
  • H-O. Pettit et al.

    Pharmacol. Biochem. Behav.

    (1989)
  • Y.L. Hurd et al.

    Brain Res.

    (1989)
  • H-O. Pettit et al.

    Brain Res.

    (1991)
  • A.O. Pfeffer et al.

    Pharmacol. Biochem. Behav.

    (1988)
  • A.O. Pfeffer et al.

    Drug Alcohol Depend

    (1986)
  • M.B. Waller et al.

    Pharmacol. Biochem. Behav.

    (1986)
  • Z. Amit et al.

    Pharmacol. Biochem. Behav.

    (1982)
  • J.M. Van Ree et al.

    Life Sci.

    (1979)
  • C.L. Broekkamp et al.

    Pharmacol. Biochem. Behav.

    (1979)
  • M.E. Olds

    Brain Res.

    (1979)
  • T.H. Hand et al.

    Brain Res.

    (1988)
  • G.T. Bain et al.

    Life Sci.

    (1987)
  • J.R. Weeks et al.

    Prostaglandins

    (1976)
  • F.J. Vaccarino et al.

    Pharmacol. Biochem. Behav.

    (1985)
  • M.D. Britt et al.

    Brain Res.

    (1983)
  • R.L. Schroeder et al.

    Neurosci. Lett.

    (1991)
  • N.E. Goeders et al.

    Pharmacol. Biochem. Behav.

    (1984)
  • L. Stinus

    Biol. Psychiatry

    (1989)
  • G. Richards et al.

    Semin. Neurosci.

    (1991)
  • R. Dorow et al.

    Lancet

    (1983)
  • M.G. Corda et al.

    Neuropharmacology

    (1986)
  • A.M. Allan et al.

    Pharmacol. Biochem. Behav.

    (1987)
  • H.H. Samson et al.

    Pharmacol. Biochem. Behav.

    (1987)
  • C. Szostak et al.

    Neuropharmacology

    (1987)
  • C.B. Hubner et al.

    Brain Res.

    (1990)
  • L. Peyrin et al.

    Brain Res.

    (1982)
  • G.F. Alheid et al.

    Neuroscience

    (1988)
  • B.J. Spiegler et al.

    Behav. Brain Res.

    (1981)
  • G.F. Koob et al.
  • A. Dahlström et al.

    Acta Physiol. Scand.

    (1964)
  • O. Lindvall
  • J.H. Fallon et al.

    J. Comp. Neurol.

    (1978)
  • M. Le Moal et al.

    Physiol. Rev.

    (1991)
  • N.R. Swerdlow et al.

    Behav. Brain Sci.

    (1987)
  • J.R. Blackburn et al.

    Behav. Neurosci.

    (1987)
  • R.A. Wise et al.

    Psychol. Rev.

    (1987)
  • W.M. Davis et al.

    J. Pharm. Pharmacol.

    (1975)
  • H. DeWit et al.

    Can. J. Psychol.

    (1977)
  • W.H. Lyness et al.

    Pharmacol. Biochem. Behav.

    (1979)
  • M.T. Martin-Iverson et al.

    Psychopharmacology

    (1986)
  • Cited by (1944)

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