Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity

doi:10.1016/0006-8993(85)91586-0

Brain Research

Volume 333, Issue 2, 6 May 1985, Pages 325-329

https://doi.org/10.1016/0006-8993(85)91586-0 Get rights and content

When a substance is pressure-injected from a micropipette into the extracellular space of the brain it may either form a cavity or it may infiltrate the extracellular space. In either case subsequent diffusion is governed by the volume fraction and tortuosity of the brain tissue as well as the diffusion coefficient of the substance itself. Appropriate equations, solutions and approximations to these problems are discussed. The results are relevant to the interpretation of studies on neuropharmacology and in situ electrochemistry.

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Citation Excerpt :
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Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity

Conduction of Heat in Solids

The Mathematics of Diffusion

Diffusion processes measured at microvoltametric electrodes in brain tissue

J. Electroanalyt. Chem.

A comparison of the release of substance P and some synthetic analogues from micropipettes by microiontophoresis or pressure

Neuropharmacology

Effect of α-bungarotoxin on retinotectal synaptic transmission in the goldfish and the toad

Neuroscience

On the theorems for local volume averaging of multiphase systems

Int. J. Multiphase Flow