Elsevier

Brain Research

Volume 270, Issue 2, 4 July 1983, Pages 285-288
Brain Research

Alpha-methyltyrosine attenuates and reserpine increases methamphetamine-induced neuronal changes

https://doi.org/10.1016/0006-8993(83)90602-9Get rights and content

Abstract

The repeated administration of methamphetamine to rats has been shown to cause a long-lasting depletion of dopamine in various brain regions. In the first study, the effects of pretreatment with alphamethyltyrosine (AMT) or reserpine on the long-lasting methamphetamine-induced dopamine depletion were examined. In the second study, the effects of AMT and reserpine on central dopamine levels were measured in rats previously treated with methamphetamine. Pretreatment with AMT attenuated the long-lasting dopamine depletion induced by methamphetamine, whereas, pretreatment with reserpine increased the depletion. The acute effects of AMT and reserpine on brain dopamine were not altered when administered two weeks after the last methamphetamine injection.

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*

Present address: Department of Psychology, Rutgers University, New Brunswick, NJ 08903, U.S.A.

**

Present address: Department of Pharmacology, Wright State University, Dayton, OH 45435, U.S.A.

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