Changes in apomorphine-induced stereotypy as a result of subacute neuroleptic treatment correlates with increased D-2 receptors, but not with increases in D-1 receptors
References (32)
- et al.
Neuropharmacology
(1974) - et al.
Life Sci.
(1976) - et al.
Life Sci.
(1977) - et al.
Biochem. Pharmac.
(1982) - et al.
Eur. J. Pharmac.
(1980) - et al.
Biochem. Pharmac.
(1975) - et al.
Life Sci.
(1975) - et al.
Eur. J. Pharmac.
(1980) Life Sci.
(1981)Prog. Neuro-Psychopharmac.
(1978)
Neuropharmacology
Life Sci.
Nature, Lond.
Nature, Lond.
Pharmac. Rev.
Nature, Lond.
Cited by (77)
Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats
2021, NeuropharmacologyCitation Excerpt :When VTA D2 autoreceptors are stimulated by somatodendritic dopamine release, this reduces the excitability of local dopamine neurons. If chronic antipsychotic exposure upregulates D2 receptors in the VTA [as it does in the striatum (Burt et al., 1977; Fleminger et al., 1983)], dopamine activation of upregulated D2 autoreceptors could produce enhanced autoregulatory inhibitory feedback on dopamine neurons, thereby attenuating further dopamine release from both somatodendritic and terminal sites in antipsychotic-exposed rats. This in turn could explain why we did not observe enhanced locomotor responses to intra-VTA DAMGO or neurotensin in these rats.
Antipsychotic-evoked dopamine supersensitivity
2020, NeuropharmacologyCitation Excerpt :Both typical and atypical antipsychotic drugs can produce dopamine supersensitivity, but supersensitivity might persist longer after cessation of treatment with typical antipsychotics. Animals previously exposed to the typical antipsychotics haloperidol (Smith and Davis, 1975; Vonvoigtlander et al., 1975; Montanaro et al., 1982; Fleminger et al., 1983; Marin and Chase, 1993; Samaha et al., 2007; Fukushiro et al., 2008; Tadokoro et al., 2012; Bedard et al., 2013), sulpiride (Montanaro et al., 1982; Fleminger et al., 1983), trifluoperazine (Clow et al., 1980) or thioridazine (Vonvoigtlander et al., 1975; Clow et al., 1980; Calza et al., 1990) are supersensitive to the behavioural effects of dopamine agonists. In contrast, animals previously exposed to the atypical antipsychotics olanzapine (Samaha et al., 2007; Bedard et al., 2013), aripiprazole (Tadokoro et al., 2012), risperidone (Carvalho et al., 2009) or ziprasidone (Fukushiro et al., 2008) generally show a normal locomotor response to dopamine agonists, suggesting no dopamine supersensitivity.
Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats
2003, NeuropharmacologyEffects of haloperidol on rat behavior and density of dopaminergic D2-like receptors
2003, Behavioural ProcessesEffects of melatonin on behavioral dopaminergic supersensitivity
2003, Life Sciences