Glutamate triggers internucleosomal DNA cleavage in neuronal cells
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Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons
2011, Neurobiology of AgingCitation Excerpt :One way to distinguish between these possibilities was to test the effect of CYP46 knockdown after the intraperitoneal injection of kainic acid (KA) (see Section 2). This is an established procedure to trigger seizures and excitotoxic neuronal injury (Bettler and Mulle, 1995; Fraker et al., 1995; Kure et al., 1991) and would therefore distinguish if Cyp46 participates in survival under extreme stress. In this experiment, neurons transduced with control virus did not show signs of cell damage or death, neither in young (data not shown) nor in old animals (Fig. 7B), indicating that the stress paradigm utilized was not cytotoxic at this time.
Recurrent spatiotemporal firing patterns in large spiking neural networks with ontogenetic and epigenetic processes
2010, Journal of Physiology ParisTemporal and spatial expression of preprotachykinin A mRNA in the developing filial mice brain after maternal administration of monosodium glutamate at a late stage of pregnancy
2007, NeuroscienceCitation Excerpt :Pathophysiological studies suggest that EAAss and calcium accumulation may contribute to selective neuronal loss. EAAs such as Glu are known to be neurotoxic and can increase calcium influxes and induce apoptosis in neurons under certain conditions (Choi et al., 2006; Kure et al., 1991; Tang et al., 2005). Glu activates postsynaptic receptors including the ligand-gated iontropic receptors (iGluRs) and the G protein-coupled metabotropic receptors (mGluRs) when released from presynaptic terminals (Nakanishi, 1992; Scatton, 1993).
Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
2006, Brain ResearchCitation Excerpt :Also, glutamate is a major excitatory neurotransmitter in the brain and a potent excitotoxin. Exposure of neuronal cultures to micromolar concentrations of glutamate has been reported to lead to neurotoxicity (Choi, 1988) and induce neuronal apoptosis (Kure et al., 1991). Given the abundance of agmatine in the hippocampus (Feng et al., 1997; Reis et al., 1998), studying the effects of agmatine on hippocampal neurons will provide important information regarding the potential role of this proposed neurotransmitter in this area.
Increase in apoptosis with neural differentiation and shortening of the lifespan of P19 cells overexpressing tau
2006, Neurochemistry InternationalGlutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line
2004, Molecular Brain Research