Skip to main content

Advertisement

Log in

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice

  • Express communication
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

Apolipoprotein E (apoE) has been implicated as a risk factor for Alzheimer’s disease and in the deposition, fibrillogenesis, and clearance of the amyloid β-peptide (Aβ). To examine the in vivo interactions between apoE and Aβ deposition, we examined 12-month-old transgenic (tg) mice expressing human amyloid precursor protein (APP) with the V717F mutation (APPV717F homozygous) on an APOE null background. Elimination of APOE resulted in a redistribution and alteration in the character of Aβ deposition in homozygous APPV717F tg mice, with a dramatic reduction in cortical and dentate gyrus deposition, prominent increase in diffuse CA1 and CA3 deposition, and prevention of the formation of thioflavin-S-positive deposits. These alterations in Aβ deposition were not mediated by significant changes in regional APP expression, low-density lipoprotein receptor-related protein expression, or soluble Aβ levels. Thus, apoE in APPV717F tg mice not only affects the amount and form of Aβ deposition, but also the anatomical distribution of diffuse Aβ deposits. The APPV717F tg mouse can serve as a model to investigate genetic influences on the vulnerability of specific neuroanatomical regions to Aβ deposition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 11 April 2000 / Revised, accepted: 25 May 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Irizarry, M., Cheung, B., Rebeck, G. et al. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice. Acta Neuropathol 100, 451–458 (2000). https://doi.org/10.1007/s004010000263

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004010000263

Navigation